SynthesisTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2014
An updated meta-analysis of the association between GSTM1 polymorphism and colorectal cancer in Asians.
Synthesis in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 6 syntheses or guidelines pooled it, 11 citations in OpenAlex.
- A joint transcriptome-wide association study across multiple tissues identifies candidate breast cancer susceptibility genes.American journal of human genetics · 2023Pooled it
- Cross-ancestry GWAS meta-analysis identifies six breast cancer loci in African and European ancestry women.Nature communications · 2021Pooled it
- Individual and combined effects of GSTM1 and GSTT1 polymorphisms on colorectal cancer risk: an updated meta-analysis.Bioscience reports · 2020Pooled it
- The association of low penetrance genetic risk modifiers with colorectal cancer in lynch syndrome patients: a systematic review and meta-analysis.Familial cancer · 2018Pooled it
- Glutathione S-transferase M1 null genotype related to poor prognosis of colorectal cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Pooled it
- GSTM1 polymorphism contribute to colorectal cancer in Asian populations: a prospective meta-analysis.Scientific reports · 2015Pooled it
- Copper metabolism patterns and tumor microenvironment characterization in colon adenocarcinoma.Frontiers in oncology · 2022Article
- Risk of Colorectal Carcinoma May Predispose to the Genetic Variants of theInternational journal of general medicine · 2021Article
- The Role of Isothiocyanates as Cancer Chemo-Preventive, Chemo-Therapeutic and Anti-Melanoma Agents.Antioxidants (Basel, Switzerland) · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glutathione S-transferases (GSTs) are a large family of phase II detoxification enzymes that are expressed in many tissues and play critical roles in protecting hosts against cancer. The association of glutathione S-transferase M1 (GSTM1) polymorphism with susceptibility to colorectal cancer in Asians has not been well established. We performed a meta-analysis to quantitatively assess the association between GSTM1 polymorphism and colorectal cancer in Asians. We systematically searched the PubMed and Embase databases to identify the eligible studies. Finally, 17 eligible studies with 5,907 cases and 9,726 controls were included into the meta-analysis. The pooled odds ratio (OR) with its 95 % confidence intervals (95 %CI) was used to assess the association. The meta-analysis of those included studies suggests that GSTM1 null genotype was significantly associated with colorectal cancer risk in Asians (OR = 1.14, 95 %CI = 1.013-1.29, P = 0.03). The cumulative meta-analyses showed a trend of an obvious association between the GSTM1 null genotype and risk of colorectal cancer in Asians as information accumulated by year. Thus, there is an obvious association between the GSTM1 null genotype and risk of colorectal cancer in Asians.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.