ReviewEndocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
New tools for weight-loss therapy enable a more robust medical model for obesity treatment: rationale for a complications-centric approach.
Review in Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pharmacological and non-pharmacological strategies for obese women with subfertility.The Cochrane database of systematic reviews · 2021 · on this mapPooled it
- Long-term drug treatment for obesity: a systematic and clinical review.JAMA · 2014 · on this mapPooled it
- Effect of liraglutide on cardiometabolic profile and on bioelectrical impedance analysis in patients with obesity and metabolic syndrome.Scientific reports · 2023Trial
- Systemic Inflammation in Severe Obese Patients Undergoing Surgery for Obesity and Weight-Related Diseases.Obesity surgery · 2018Trial
- Introduction and methodology: Standards of Care in Overweight and Obesity-2025.BMJ open diabetes research & care · 2025Review
- The Effect of Exenatide on Platelets Ratio Index and Fibrosis-4 Index in Obese Patients With Diabetes Mellitus.International journal of endocrinology · 2025Article
- The potential impact fraction of population weight reduction scenarios on non-communicable diseases in Belgium: application of the g-computation approach.BMC medical research methodology · 2024Article
- Association between long-term weight loss and obesity-related complications defined by Edmonton obesity staging system: analysis from the NHANES (2011-2018).European journal of clinical nutrition · 2024Article
- Future Medications for Obesity and Clinical Implications.Diabetes spectrum : a publication of the American Diabetes Association · 2024Article
- A Focus on the Pharmacotherapy of Obesity.Diabetes spectrum : a publication of the American Diabetes Association · 2024Article
- Emerging Role of GLP-1 Agonists in Obesity: A Comprehensive Review of Randomised Controlled Trials.International journal of molecular sciences · 2023Review
- Article
- New Horizons. A New Paradigm for Treating to Target with Second-Generation Obesity Medications.The Journal of clinical endocrinology and metabolism · 2022Article
- Effect of Acupoint Catgut Embedding for Middle-Aged Obesity: A Multicentre, Randomised, Sham-Controlled Trial.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Obstetrician-Gynecologists' Strategies for Patient Initiation and Maintenance of Antiobesity Treatment with Glucagon-Like Peptide-1 Receptor Agonists.Journal of women's health (2002) · 2021Review
- Association between RBC Indices, Anemia, and Obesity-Related Diseases Affected by Body Mass Index in Iranian Kurdish Population: Results from a Cohort Study in Western Iran.International journal of endocrinology · 2021Article
- Economic value of nonsurgical weight loss in adults with obesity.Journal of managed care & specialty pharmacy · 2021Article
- Using multi-disciplinary teams to treat obese patients helps improve clinical efficacy: the general practitioner's perspective.American journal of translational research · 2021Article
- Body Composition and Metabolic Improvement in Patients Followed Up by a Multidisciplinary Team for Obesity in China.Journal of diabetes research · 2021Article
- Proposal for a Scientifically Correct and Medically Actionable Disease Classification System (ICD) for Obesity.Obesity (Silver Spring, Md.) · 2020Review
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
objectiveRecent advances in lifestyle intervention programs, pharmacotherapy, and bariatric surgery have enabled the development of medical models for the treatment of obesity. Regarding pharmacotherapy, in 2012 the U.S. Food and Drug Administration approved two new effective and safe weight-loss medications, phentermine/topiramate extended release and lorcaserin, which has greatly augmented options for medically assisted weight loss.
methodsThe rationale for advantages of a complications-centric medical model over current body mass index (BMI)-centric indications for therapy is examined.
resultsCurrently, the baseline BMI level is the principle determinant of indications for obesity treatment using medication and surgery. However, the BMI-centric approach fails to target therapy to those obese patients who will benefit most from weight loss. In contrast, a complications-centric medical model is proposed that will earmark the modality and intensity of the therapeutic intervention based on the presence and severity of complications that can be ameliorated by weight loss.
conclusionThe complications-centric approach to "medicalizing" obesity care employs weight loss primarily as a tool to treat obesity-related complications and promotes the optimization of health outcomes, the benefit/risk ratio, and the cost-effectiveness of therapy.
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Registered trials
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