ArticleCerebellum (London, England)2014
Prefrontal control of cerebellum-dependent associative motor learning.
Article in Cerebellum (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Neuronal dynamics of cerebellum and medial prefrontal cortex in adaptive motor timing.Nature communications · 2025Article
- Ventromedial Thalamus-Projecting DCN Neurons Modulate Associative Sensorimotor Responses in Mice.Neuroscience bulletin · 2022Article
- Role of cerebellar cortex in associative learning and memory in guinea pigs.Open life sciences · 2022Article
- A method for combining multiple-units readout of optogenetic control with natural stimulation-evoked eyeblink conditioning in freely-moving mice.Scientific reports · 2019Article
- Long Trace Eyeblink Conditioning Is Largely Preserved in Essential Tremor.Cerebellum (London, England) · 2019Article
- Infusions of scopolamine in dorsal hippocampus reduce anticipatory responding in an appetitive trace conditioning procedure.Brain and behavior · 2018Article
- Prefrontal Cortex Dysfunction in Fragile X Mice Depends on the Continued Absence of Fragile X Mental Retardation Protein in the Adult Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Scopolamine Impairs Appetitive But Not Aversive Trace Conditioning: Role of the Medial Prefrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Theta synchronization between medial prefrontal cortex and cerebellum is associated with adaptive performance of associative learning behavior.Scientific reports · 2016Article
- Effects of dopamine D1 modulation of the anterior cingulate cortex in a fear conditioning procedure.Progress in neuro-psychopharmacology & biological psychiatry · 2016Article
- Neuroplasticity subserving the operation of brain-machine interfaces.Neurobiology of disease · 2015Review
- Eyeblink Conditioning and Novel Object Recognition in the Rabbit: Behavioral Paradigms for Assaying Psychiatric Diseases.Frontiers in psychiatry · 2015Review
- Timing Tasks Synchronize Cerebellar and Frontal Ramping Activity and Theta Oscillations: Implications for Cerebellar Stimulation in Diseases of Impaired Cognition.Frontiers in psychiatry · 2015Review
- Modification of persistent responses in medial prefrontal cortex during learning in trace eyeblink conditioning.Journal of neurophysiology · 2014Article
- The therapeutic potential of the cerebellum in schizophrenia.Frontiers in systems neuroscience · 2014Article
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Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Behavioral studies have demonstrated that both medial prefrontal cortex (mPFC) and cerebellum play critical roles in trace eyeblink conditioning. However, little is known regarding the mechanism by which the two brain regions interact. By use of electrical stimulation of the caudal mPFC as a conditioned stimulus, we show evidence that persistent outputs from the mPFC to cerebellum are necessary and sufficient for the acquisition and expression of a trace conditioned response (CR)-like response. Specifically, the persistent outputs of caudal mPFC are relayed to the cerebellum via the rostral part of lateral pontine nuclei. Moreover, interfering with persistent activity by blockade of the muscarinic Ach receptor in the caudal mPFC impairs the expression of learned trace CRs. These results suggest an important way for the caudal mPFC to interact with the cerebellum during associative motor learning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.