ArticleEuropean journal of clinical pharmacology2014
Risk factors for non-adherence to antidepressant treatment in patients with mood disorders.
Article in European journal of clinical pharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- What is the impact of antidepressant side effects on medication adherence among adult patients diagnosed with depressive disorder: A systematic review.Journal of psychopharmacology (Oxford, England) · 2024Pooled it
- Mapping modifiable determinants of medication adherence in bipolar disorder (BD) to the theoretical domains framework (TDF): a systematic review.Psychological medicine · 2021Pooled it
- A randomized, double-blind study comparing the efficacy and safety of trazodone once-a-day and venlafaxine extended-release for the treatment of patients with major depressive disorder.International clinical psychopharmacology · 2020Trial
- Learning to experience side effects after antidepressant intake - Results from a randomized, controlled, double-blind study.Psychopharmacology · 2017Trial
- Antidepressant prescribing patterns and patient-reported adverse effects: a cross-sectional study from Pakistan.Annals of general psychiatry · 2026Article
- Probing Public Perceptions of Antidepressants on Social Media: Mixed Methods Study.JMIR formative research · 2025Article
- Psychosocial Determinants of Antidepressant Adherence Among Hungarian Adults: A Cross-Sectional Online Survey.Patient preference and adherence · 2025Article
- The Impact of Mood Disorders on Adherence, on Life Satisfaction and Acceptance of Illness-Cross-Sectional Observational Study.Healthcare (Basel, Switzerland) · 2024Article
- Role of trazodone in treatment of major depressive disorder: an update.Annals of general psychiatry · 2023Review
- Article
- Factors Associated With Non-adherence to Anti-depressant Medication in Adults: A Systematic Review and Meta-Analysis.Cureus · 2023Review
- A risk identification model for detection of patients at risk of antidepressant discontinuation.Frontiers in artificial intelligence · 2023Article
- Barriers and Facilitating Factors of Adherence to Antidepressant Treatments: An Exploratory Qualitative Study with Patients and Psychiatrists.International journal of environmental research and public health · 2022Article
- Association between childhood trauma and medication adherence among patients with major depressive disorder: the moderating role of resilience.BMC psychiatry · 2022Article
- Examining the Use of Antidepressants for Adolescents with Depression/Anxiety Who Regularly Use Cannabis: A Narrative Review.International journal of environmental research and public health · 2022Review
- An Active Inference Approach to Dissecting Reasons for Nonadherence to Antidepressants.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Article
- Factors Associated with Antidepressant Medication Non-adherenceTurkish journal of pharmaceutical sciences · 2021Article
- Acupuncture: A Promising Approach for Comorbid Depression and Insomnia in Perimenopause.Nature and science of sleep · 2021Review
- Informing About the Nocebo Effect Affects Patients' Need for Information About Antidepressants-An Experimental Online Study.Frontiers in psychiatry · 2021Article
- Evaluating Behavioral and Linguistic Changes During Drug Treatment for Depression Using Tweets in Spanish: Pairwise Comparison Study.Journal of medical Internet research · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAdherence to antidepressant therapy by patients with depressive disorders is essential not only to achieve a positive patient outcome but also to prevent a relapse. The aim of this study was to identify potential modelling factors influencing adherence to antidepressant treatment by patients with mood disorders in the community mental health care setting
methodsA total of 160 consecutive psychiatric outpatients attending two Community Mental Health Centres on Tenerife Island between September 2011 and May 2012 were asked to participate in the study; of these, 145 accepted. The Morisky self-report scale was used to assess adherence. The potential predictors examined included socio-demographic, clinical and therapeutic variables. The Clinical Global Impression-Severity and -Improvement scales and the Beck Depression Inventory were used for clinical assessment. Drug treatment side-effects were assessed using the "Self-report Antidepressant Side-Effect Checklist." All participants were also asked to complete the "Drug Attitude Inventory" (DAI), "Beliefs about Medicine Questionnaire" (BMQ), and "Leeds Attitude towards concordance Scale". Discriminant analyses were performed to predict non-adherence.
resultsThere was no clear correlation between adherence and the socio-demographic variables examined, but adherence was related to a positive attitude of the patients towards his/her treatment (DAI) and low scores in the BMQ-Harm and -Concern subscales. Non-adherence was also related to an increasing severity of depression and to the presence and severity of side-effects.
conclusionsAmong our study cohort, the profiles of adherent patients to antidepressant treatment were more closely associated with each patient's attitudes and beliefs than to objective socio-demographic variables. The severity of depression played a relevant role in adherence, but whether this role is direct or an interaction with several concurrent factors is not yet clear. Side-effects were also closely related to adherence, as conditioned by frequent polypharmacy.
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