ArticlePLoS biology2013
The extraordinary evolutionary history of the reticuloendotheliosis viruses.
Article in PLoS biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed.
- RNAViruses · 2026Review
- Pathological mechanisms of avian viral oncogenesis: The central role of MicroRNA.Poultry science · 2026Review
- Identification of a Novel Antigenic Epitope in Envelope Protein of Avian Reticuloendotheliosis Virus.Veterinary sciences · 2026Article
- Gammaretrovirus Infections in Humans in the Past, Present, and Future: Have We Defeated the Pathogen?Pathogens (Basel, Switzerland) · 2026Review
- Virological perspectives of the current situation of oncogenic viruses in Egypt: a review.Infectious agents and cancer · 2025Review
- First Complete Genome of Reticuloendotheliosis Virus in a Mallard Duck from Brazil: Phylogenetic Insights and Evolutionary Analysis.Pathogens (Basel, Switzerland) · 2025Article
- Invasion and Amplification of Endogenous Retroviruses in Dasyuridae Marsupial Genomes.Molecular biology and evolution · 2024Article
- Dynamic Evolution of Retroviral Envelope Genes in Egg-Laying Mammalian Genomes.Molecular biology and evolution · 2023Article
- Article
- Article
- Cross-species transmission of an ancient endogenous retrovirus and convergent co-option of its envelope gene in two mammalian orders.PLoS genetics · 2022Article
- Epidemic of cutaneous fowlpox in a naïve population of chickens and turkeys in Austria: Detailed phylogenetic analysis indicates co-evolution of fowlpox virus with reticuloendotheliosis virus.Transboundary and emerging diseases · 2022Article
- Evolution and Genetic Diversity of the Retroviral Envelope in Anamniotes.Journal of virology · 2022Article
- Complete Genome Characterization of Reticuloendotheliosis Virus Detected in Chickens with Multiple Viral Coinfections.Viruses · 2022Article
- Discovery of two novelFrontiers in microbiology · 2022Article
- Marek's Disease Virus and Reticuloendotheliosis Virus Coinfection Enhances Viral Replication and Alters Cellular Protein Profiles.Frontiers in veterinary science · 2022Article
- Viruses' evolvement as a never stopping perpetuum mobile.Journal of virological methods · 2021Review
- Article
- The characterization of two novel neotropical primate papillomaviruses supports the ancient within-species diversity model.Virus evolution · 2020Article
- Multifunctional miR-155 Pathway in Avian Oncogenic Virus-Induced Neoplastic Diseases.Non-coding RNA · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The reticuloendotheliosis viruses (REVs) comprise several closely related amphotropic retroviruses isolated from birds. These viruses exhibit several highly unusual characteristics that have not so far been adequately explained, including their extremely close relationship to mammalian retroviruses, and their presence as endogenous sequences within the genomes of certain large DNA viruses. We present evidence for an iatrogenic origin of REVs that accounts for these phenomena. Firstly, we identify endogenous retroviral fossils in mammalian genomes that share a unique recombinant structure with REVs-unequivocally demonstrating that REVs derive directly from mammalian retroviruses. Secondly, through sequencing of archived REV isolates, we confirm that contaminated Plasmodium lophurae stocks have been the source of multiple REV outbreaks in experimentally infected birds. Finally, we show that both phylogenetic and historical evidence support a scenario wherein REVs originated as mammalian retroviruses that were accidentally introduced into avian hosts in the late 1930s, during experimental studies of P. lophurae, and subsequently integrated into the fowlpox virus (FWPV) and gallid herpesvirus type 2 (GHV-2) genomes, generating recombinant DNA viruses that now circulate in wild birds and poultry. Our findings provide a novel perspective on the origin and evolution of REV, and indicate that horizontal gene transfer between virus families can expand the impact of iatrogenic transmission events.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.