ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2014
Transition to sarcopenia and determinants of transitions in older adults: a population-based study.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 4 syntheses or guidelines pooled it, 108 citations in OpenAlex.
- Habitual physical activity and sarcopenia: a systematic review and meta-analysis of prospective cohort studies.Journal of global health · 2026Pooled it
- Associated Factors of Sarcopenia in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis.Nutrients · 2021Pooled it
- Relationship between sarcopenia and physical activity in older people: a systematic review and meta-analysis.Clinical interventions in aging · 2017Pooled it
- Prevalence of and interventions for sarcopenia in ageing adults: a systematic review. Report of the International Sarcopenia Initiative (EWGSOP and IWGS).Age and ageing · 2014Pooled it
- Relationship Between Sarcopenia and Intensive Blood Pressure Control Efficacy and Safety: A Secondary Analysis of SPRINT.Hypertension (Dallas, Tex. : 1979) · 2024Trial
- Automated Muscle Measurement on Chest CT Predicts All-Cause Mortality in Older Adults From the National Lung Screening Trial.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Trial
- Establishment of Prediction Equations of Lean Body Mass Suitable for Chinese Adults.BioMed research international · 2019Trial
- Baseline characteristics of participants in the VITamin D and OmegA-3 TriaL (VITAL): Effects on Bone Structure and Architecture.Contemporary clinical trials · 2018Trial
- Comparative performance of current definitions of sarcopenia against the prospective incidence of falls among community-dwelling seniors age 65 and older.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015Trial
- Disentangling the association between chronic pain and sarcopenia-related traits: A bidirectional Mendelian randomization study.The Journal of international medical research · 2026Article
- Physical Activity Types and Sarcopenia Components Among Middle-Aged and Older People: A Cross-Sectional Study.Calcified tissue international · 2026Article
- Longitudinal associations between changes in muscle strength, muscle mass, and physical performance and health-related quality of life in older adults: a four-year analysis from the SarcoPhAge cohort.European geriatric medicine · 2026Article
- Sarcopenia trajectories and associated factors in older adults: evidence from the China health and retirement longitudinal study.BMC geriatrics · 2026Article
- Dynamic conversion and associated risk factors between mutually exclusive muscle health states in geriatric population.BMC geriatrics · 2025Article
- Health economics evaluation of screening for sarcopenia among community-dwelling older persons.BMC public health · 2025Article
- Changes in Sarcopenia Status and Subsequent Cardiovascular Outcomes: Prospective Cohort Study.JMIR aging · 2025Observational
- Association of Alzheimer's Disease Blood Biomarkers With Sarcopenia Incidence and Progression: A 12-Year Population-Based Study.Journal of cachexia, sarcopenia and muscle · 2025Article
- Dietary influence on the link between depression and muscle mass and muscle strength: exploring interaction and mediation effects.BMC public health · 2025Article
- Association between smoking status and sarcopenia among middle-aged and older adults: finding from the CHARLS study.European geriatric medicine · 2025Article
- Association between Chronic Pain and Sarcopenia in Greek Community-Dwelling Older Adults: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundDiagnostic criteria for sarcopenia from appendicular lean mass (ALM), strength, and performance have been proposed, but little is known regarding the progression of sarcopenia. We examined the time course of sarcopenia and determinants of transitioning toward and away from sarcopenia.
methodsALM, gait speed, and grip strength were assessed seven times over 9 years in 2,928 initially well-functioning adults aged 70-79. Low ALM was defined as less than 7.95 kg/m(2) (men) or less than 6.24 kg/m(2) (women), low performance as gait speed less than 1.0 m/s, low strength as grip strength less than 30 kg (men) or less than 20 kg (women). Presarcopenia was defined as low ALM and sarcopenia as low ALM with low performance or low strength. Hidden Markov modeling was used to characterize states of ALM, strength, and performance and model transitions leading to sarcopenia and death. Determinants of transitioning toward and away from sarcopenia were examined with logistic regression.
resultsInitially, 54% of participants had normal ALM, strength, and performance; 21% had presarcopenia; 5% had sarcopenia; and 20% had intermediate characteristics. Of participants with normal ALM, strength, and performance, 1% transitioned to presarcopenia and none transitioned to sarcopenia. The greatest transition to sarcopenia (7%) was in presarcopenic individuals. Low-functioning and sarcopenia states were more likely to lead to death (12% and 13%). Higher body mass index (p < .001) and pain (p = .05) predicted transition toward sarcopenia, whereas moderate activity predicted transition from presarcopenia to more normal states (p = .02).
conclusionsPain, physical activity, and body mass index, potentially modifiable factors, are determinants of transitions. Promotion of health approaching old age is important as few individuals transition away from their initial state.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.