Trial reportJournal of gastroenterology2014
Effects of mosapride on esophageal motor activity and esophagogastric junction compliance in healthy volunteers.
Trial report in Journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Normative values for esophageal functional lumen imaging probe measurements: A meta-analysis.Neurogastroenterology and motility · 2022Pooled it
- Esophagogastric junction distensibility assessed using the functional lumen imaging probe.World journal of gastroenterology · 2017Pooled it
- Acute Effects of the 5-Hydroxytryptamine Type 4 Receptor Agonist Mosapride on Pharyngeal Swallowing Physiology in Adults.The Kaohsiung journal of medical sciences · 2026Trial
- Effects of acotiamide on esophageal motor function and gastroesophageal reflux in healthy volunteers.BMC gastroenterology · 2015Trial
- Management of Ineffective Esophageal Hypomotility.Frontiers in pharmacology · 2021Review
- Mosapride Improves Lower Esophageal Sphincter and Esophageal Body Function in Patients With Minor Disorders of Esophageal Peristalsis.Journal of neurogastroenterology and motility · 2020Article
- Acotiamide Has No Effects on Esophageal Motor Activity or Esophagogastric Junction Compliance.Journal of neurogastroenterology and motility · 2018Article
- Application of the Functional Lumen Imaging Probe to Esophageal Disorders.Current treatment options in gastroenterology · 2017Review
- Functional Lumen Imaging Probe for the Management of Esophageal Disorders: Expert Review From the Clinical Practice Updates Committee of the AGA Institute.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2017Review
- Functional lumen imaging probe: The FLIP side of esophageal disease.Current opinion in gastroenterology · 2016Review
- Effects of Metoclopramide on Esophageal Motor Activity and Esophagogastric Junction Compliance in Healthy Volunteers.Journal of neurogastroenterology and motility · 2016Article
- Functional lumen imaging of the gastrointestinal tract.Journal of gastroenterology · 2015Review
- Buspirone, a new drug for the management of patients with ineffective esophageal motility?United European gastroenterology journal · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe effects of the prokinetic drug mosapride on esophageal motor activity vary at standard doses. In addition to esophageal motor activities, compliance of the esophagogastric junction (EGJ) is important for prevention of gastroesophageal reflux. However, the effects of mosapride on EGJ compliance have not been reported. Here, we investigated the effects of high-dose mosapride on esophageal motor activities and EGJ compliance.
methodsNine healthy volunteers were enrolled in the study. Peristaltic esophageal contraction and lower esophageal sphincter pressures before and after administration of 40 mg mosapride were examined by high resolution esophageal manometry. Esophageal compliance was also investigated by intra-esophageal impedance planimetry (EndoFLIP(®)).
resultsHigh-dose mosapride augmented peristaltic contractions, especially in the distal esophageal segments (P < 0.05). The mean resting lower esophageal sphincter pressure was elevated from 25.0 mmHg before administration to 28.9 mmHg after (P < 0.05). In addition, mosapride significantly reduced EGJ compliance (P < 0.05).
conclusionsMosapride at 40 mg augmented esophageal motor activities and reduced EGJ compliance in healthy volunteers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.