ArticleNature neuroscience2013
Neuropeptide signaling remodels chemosensory circuit composition in Caenorhabditis elegans.
Article in Nature neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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64 citing papers in PubMed, 111 citations in OpenAlex.
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- Neural network features distinguish chemosensory stimuli in Caenorhabditis elegans.PLoS computational biology · 2021Article
- Plasticity in gustatory and nociceptive neurons controls decision making in C. elegans salt navigation.Communications biology · 2021Article
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4 more citing papers are in PubMed but not listed here.
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2 authors at 1 institution in 1 country.
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Abstract
Neural circuits detect environmental changes and drive behavior. The routes of information flow through dense neural networks are dynamic, but the mechanisms underlying this circuit flexibility are poorly understood. Here, we define a sensory context-dependent and neuropeptide-regulated switch in the composition of a C. elegans salt sensory circuit. The primary salt detectors, ASE sensory neurons, used BLI-4 endoprotease-dependent cleavage to release the insulin-like peptide INS-6 in response to large, but not small, changes in external salt stimuli. Insulins, signaling through the insulin receptor DAF-2, functionally switched the AWC olfactory sensory neuron into an interneuron in the salt circuit. Worms with disrupted insulin signaling had deficits in salt attraction, suggesting that peptidergic signaling potentiates responses to high salt stimuli, which may promote ion homeostasis. Our results indicate that sensory context and neuropeptide signaling modify neural networks and suggest general mechanisms for generating flexible behavioral outputs by modulating neural circuit composition.
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