Trial reportNature neuroscience2013
Online evaluation of novel choices by simultaneous representation of multiple memories.
Trial report in Nature neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 138 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
138 citing papers in PubMed, 290 citations in OpenAlex.
- Interactions between human orbitofrontal cortex and hippocampus support model-based inference.PLoS biology · 2020Trial
- Dopamine D2-receptor blockade enhances decoding of prefrontal signals in humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Trial
- Memory reactivation during rest supports upcoming learning of related content.Proceedings of the National Academy of Sciences of the United States of America · 2014Trial
- Human curriculum learning of a cue combination task.Nature human behaviour · 2026Article
- Human hippocampal ripples tune cortical responses based on predicted uncertainty.Nature neuroscience · 2026Article
- The hippocampus rapidly integrates sequence representations during novel multistep predictions.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Article
- Human hippocampal ripples coordinate planning sequences and compositional representations in neocortex.Nature neuroscience · 2026Article
- Why do we need imagination-reality monitoring?Neuroscience of consciousness · 2026Article
- From Brain to Shopping Cart: Neural Signals of Willingness to Buy Innovative Products.Neuroscience bulletin · 2026Article
- Hippocampal mismatch signals are based on episodic memories and not schematic knowledge.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Active information sampling in health and disease.Neuroscience and biobehavioral reviews · 2025Review
- Differentiating Reinforcement Learning and Episodic Memory in Value-Based Decisions in Parkinson's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Disentangling the Component Processes in Complex Planning Impairments Following Ventromedial Prefrontal Lesions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Schemas, reinforcement learning and the medial prefrontal cortex.Nature reviews. Neuroscience · 2025Review
- Abstract rule generalization for composing novel meaning recruits a frontoparietal control network.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Decomposing dynamical subprocesses for compositional generalization.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Cognitive Graphs: Representational Substrates for Planning.Decision (Washington, D.C.) · 2024Article
- Article
- The role of the human hippocampus in decision-making under uncertainty.Nature human behaviour · 2024Article
- When New Experience Leads to New Knowledge: A Computational Framework for Formalizing Epistemically Transformative Experiences.Open mind : discoveries in cognitive science · 2024Article
78 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Prior experience is critical for decision-making. It enables explicit representation of potential outcomes and provides training to valuation mechanisms. However, we can also make choices in the absence of prior experience by merely imagining the consequences of a new experience. Using functional magnetic resonance imaging repetition suppression in humans, we examined how neuronal representations of novel rewards can be constructed and evaluated. A likely novel experience was constructed by invoking multiple independent memories in hippocampus and medial prefrontal cortex. This construction persisted for only a short time period, during which new associations were observed between the memories for component items. Together, these findings suggest that, in the absence of direct experience, coactivation of multiple relevant memories can provide a training signal to the valuation system that allows the consequences of new experiences to be imagined and acted on.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.