ReviewArchives of toxicology2014
Primary hepatocytes and their cultures in liver apoptosis research.
Review in Archives of toxicology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Article
- Combining human liver ECM with topographically featured electrospun scaffolds for engineering hepatic microenvironment.Scientific reports · 2024Article
- A robust reprogramming strategy for generating hepatocyte-like cells usable in pharmaco-toxicological studies.Stem cell research & therapy · 2023Article
- Cellular microarrays for assessing single-cell phenotypic changes in vascular cell populations.Biomedical microdevices · 2023Article
- The human vault RNA enhances tumorigenesis and chemoresistance through the lysosome in hepatocellular carcinoma.Autophagy · 2022Article
- In Vitro Liver Toxicity Testing of Chemicals: A Pragmatic Approach.International journal of molecular sciences · 2021Review
- Response differences of HepG2 and Primary Mouse Hepatocytes to morphological changes in electrospun PCL scaffolds.Scientific reports · 2021Article
- Article
- Current progress in hepatic tissue regeneration by tissue engineering.Journal of translational medicine · 2019Review
- Optimization of DamID for use in primary cultures of mouse hepatocytes.Methods (San Diego, Calif.) · 2019Article
- Cross-species comparison of CAR-mediated procarcinogenic key events in a 3D liver microtissue model.Toxicology reports · 2019Article
- Cellular Mechanisms of Hepatoprotection Mediated by M2-Like Macrophages.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Prolongation of liver-specific function for primary hepatocytes maintenance in 3D printed architectures.Organogenesis · 2018Article
- In vitro testing of basal cytotoxicity: Establishment of an adverse outcome pathway from chemical insult to cell death.Toxicology in vitro : an international journal published in association with BIBRA · 2017Review
- Three-dimensional (3D) printing of mouse primary hepatocytes to generate 3D hepatic structure.Annals of surgical treatment and research · 2017Article
- The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis.The Journal of clinical investigation · 2016Article
- Isolation and cultivation of adult primary bovine hepatocytes from abattoir derived liver.EXCLI journal · 2016Article
- Measurement of Apoptotic and Necrotic Cell Death in Primary Hepatocyte Cultures.Methods in molecular biology (Clifton, N.J.) · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Apoptosis not only plays a key role in physiological demise of defunct hepatocytes, but is also associated with a plethora of acute and chronic liver diseases as well as with hepatotoxicity. The present paper focuses on the modelling of this mode of programmed cell death in primary hepatocyte cultures. Particular attention is paid to the activation of spontaneous apoptosis during the isolation of hepatocytes from the liver, its progressive manifestation upon the subsequent establishment of cell cultures and simultaneously to strategies to counteract this deleterious process. In addition, currently applied approaches to experimentally induce controlled apoptosis in this in vitro setting for mechanistic research purposes and thereby its detection using relevant biomarkers are reviewed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.