Evidence map›Paper›PMID 24013364›Full record

ArticleHuman vaccines & immunotherapeutics2014

Comparative genomics of the Mycobacterium signaling architecture and implications for a novel live attenuated Tuberculosis vaccine.

Peifu Zhou, Jianping Xie

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Human vaccines & immunotherapeutics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Peifu ZhouInstitute of Modern Biopharmaceuticals; State Key Laboratory breeding Breeding base Base of Three Gorges Eco-environment and Bioresources; Eco-Environment Key Laboratory of the Three Gorges Reservoir Region; Ministry of Education; School of Life Sciences; Southwest University; Chongqing, PR China; College of Chemistry & Environmental Science; Guizhou Minzu University; Guiyang, PR China.
Jianping XieInstitute of Modern Biopharmaceuticals; State Key Laboratory breeding Breeding base Base of Three Gorges Eco-environment and Bioresources; Eco-Environment Key Laboratory of the Three Gorges Reservoir Region; Ministry of Education; School of Life Sciences; Southwest University; Chongqing, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tuberculosis (TB), caused by Mycobacterium tuberculosis (M.tb), remains a major threat to global public health. A new TB vaccine affording superior immune protection to M. bovis Bacillus Calmette-Guérin (BCG) is imperative. The advantage of a live attenuated vaccine is that it can mimic the bona fide pathogen, elicit immune responses similar to natural infection, and potentially provide more protection than other vaccines. BCG, the only vaccine and a live attenuated vaccine that is the result of cumulative mutations by serial passage of M. bovis, has provided clues for the construction of novel improved vaccines. A strategy is put forward for identifying a new live attenuated TB vaccine generated by cumulative mutation based on M.tb. Given the important role of the M.tb signaling network consisting of a two-component system, eukaryotic-like Ser/Thr protein kinase system and sigma factor system based on comparisons among M.tb H37Rv, M. bovis, and BCG, we have put a premium on this signaling circuit as the starting point for the generation of an attenuated TB vaccine.

Indexed as

Gene Expression ProfilingSignal TransductionGenomicsHost-Pathogen InteractionsHumansMycobacterium bovisMycobacterium tuberculosisTuberculosisTuberculosis VaccinesVaccines, AttenuatedTuberculosis VaccinesVaccines, Attenuatedeukaryotic-like Ser/Thr protein kinase systemMycobacterium tuberculosissigma factortwo-component systemvaccine

Identifiers

PMID24013364
PMCPMC4181023

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.