Trial reportPloS one2013
Association between body water status and acute mountain sickness.
Trial report in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Pooled it
- Association between acute mountain sickness (AMS) and age: a meta-analysis.Military Medical Research · 2018Pooled it
- Biomarkers and potential subtypes of acute mountain sickness: A state-of-the-science review.Redox biology · 2026Review
- Altitude hypoxia and hypoxemia: pathogenesis and management.Signal transduction and targeted therapy · 2026Review
- Changes in body water distribution and phase angle following rapid ascent to 3,680 m and their association with acute mountain sickness: a prospective cohort study.Frontiers in public health · 2025Article
- Hypoxia Reduces Mouse Urine Output via HIF1α-Mediated Upregulation of Renal AQP1.Kidney diseases (Basel, Switzerland) · 2024Article
- Using physical activity to advance a career in clinical nutrition.European journal of clinical nutrition · 2024Review
- Altitude illnesses.Nature reviews. Disease primers · 2024Review
- Nutrition, hydration and supplementation considerations for mountaineers in high-altitude conditions: a narrative review.Frontiers in sports and active living · 2024Review
- Diet, Supplementation and Nutritional Habits of Climbers in High Mountain Conditions.Nutrients · 2023Article
- Active ascent accelerates the time course but not the overall incidence and severity of acute mountain sickness at 3,600 m.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Analysis on alteration of road traffic casualties in western China from multi-department data in recent decade.Frontiers in public health · 2022Article
- Incidence of exercise-associated hyponatremia during a high-altitude 161-km ultramarathon.Physical activity and nutrition · 2021Article
- Bioelectrical Impedance Vector Analysis: A Valuable Tool to Monitor Daily Body Hydration Dynamics at Altitude.International journal of environmental research and public health · 2021Article
- Changes in Factors Regulating Serum Sodium Homeostasis During Two Ultra-Endurance Mountain Races of Different Distances: 69km vs. 121km.Frontiers in physiology · 2021Article
- Variability in human plasma volume responses during high-altitude sojourn.Physiological reports · 2019Article
- Body Composition and Body Weight Changes at Different Altitude Levels: A Systematic Review and Meta-Analysis.Frontiers in physiology · 2019Review
- Effects of altitude changes on mild-to-moderate closed-head injury in rats following acute high-altitude exposure.Experimental and therapeutic medicine · 2019Article
- Total Body Water Dynamics Estimated with Bioelectrical Impedance Vector Analysis and B-Type Natriuretic Peptide After Exposure to Hypobaric Hypoxia: A Field Study.High altitude medicine & biology · 2017Article
- Bioelectrical impedance vector analysis (BIVA) for measuring the hydration status in young elite synchronized swimmers.PloS one · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe present study determined the association between body fluid variation and the development of acute mountain sickness (AMS) in adults.
methodsForty-three healthy participants (26 males and 17 females, age: 26 ± 6 yr, height: 174 ± 9 cm, weight: 68 ± 12 kg) were passively exposed at a FiO2 of 12.6% (simulated altitude hypoxia of 4500 m, PiO2 = 83.9 mmHg) for 12-h. AMS severity was assessed using the Lake Louise Score (LLS). Food and drink intakes were consumed ad libitum and measured; all urine was collected. Before and after the 12-h exposure, body weight and plasma osmolality were measured and whole-body bioimpedance analysis was performed.
resultsThe overall AMS incidence was 43% (38% males, 50% females). Participants who developed AMS showed lower fluid losses (3.0 ± 0.9 vs. 4.5 ± 2.0 ml/kg/h, p = 0.002), a higher fluid retention (1.9 ± 1.5 vs. 0.6 ± 0.8 ml/kg/h, p = 0.022), greater plasma osmolality decreases (-7 ± 7 vs. -2 ± 5 mOsm/kg, p = 0.028) and a larger plasma volume expansion (11 ± 10 vs. 1 ± 15%, p = 0.041) compared to participants not developing AMS. Net water balance (fluid intake--fluid loss) and the amount of fluid loss were strong predictors whether getting sick or not (Nagelkerkes r(2) = 0.532). The LLS score was related to net water balance (r = 0.358, p = 0.018), changes in plasma osmolality (r = -0.325, p = 0.033) and sodium concentration (r = -0.305, p = 0.047). Changes in the impedance vector length were related to weight changes (r = -0.550, p<0.001), fluid intake (r = -0.533, p<0.001) and net water balance (r = -0.590, p<0.001).
conclusionsParticipants developing AMS within 12 hours showed a positive net water balance due to low fluid loss. Thus measures to avoid excess fluid retention are likely to reduce AMS symptoms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.