Evidence map›Paper›PMID 24013055›Full record

SynthesisJournal of the American College of Cardiology2013

The relationship between pre-eclampsia and peripartum cardiomyopathy: a systematic review and meta-analysis.

Natalie Bello, Iliana S Hurtado Rendon, Zoltan Arany

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of the American College of Cardiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 126 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
126citing papers in PubMed, 2 pooled it
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

126 citing papers in PubMed, 2 syntheses or guidelines pooled it, 326 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Transcriptomic Analysis ofInternational journal of molecular sciences · 2026
    Article
  5. Transcriptomic Analysis ofbioRxiv : the preprint server for biology · 2026
    Article
  6. Cardiac Implications of Preeclampsia: A Review.Journal of personalized medicine · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Observational
  12. Observational
  13. Article
  14. Article
  15. Observational
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review

66 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Natalie BelloCardiovascular Division and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
Iliana S Hurtado RendonCardiovascular Division and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
Zoltan AranyCardiovascular Division and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts. Electronic address: zarany@bidmc.harvard.edu.
Beth Israel Deaconess Medical Center · US

Funding

Training Program in Cardiovascular ResearchT32HL007374 · NHLBI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI MITTLEMAN, MURRAY A · 1985 to 2019
$7.9M
PGC-1 Coactivators in Muscle Angiogenesis IschemiaR01HL094499 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI ARANY, ZOLTAN P · 2010 to 2018
$3.7M
NHLBI NIH HHS R01 HL094499NHLBI NIH HHS T32 5T32HL007374-33NHLBI NIH HHS T32 HL007374
6 · The paper itself

Abstract

objectivesThe goal of this study was to systematically review the peripartum cardiomyopathy (PPCM) literature and determine the prevalence of pre-eclampsia (PE) in women with PPCM. Secondary analyses included evaluation of the prevalence of hypertensive disorders, multiple gestations, and multiparity.

backgroundPPCM is a significant cause of maternal and infant morbidity and mortality worldwide, yet its etiology remains unknown. PE is often cited as a risk factor for the development of PPCM and recent research suggests that PE and PPCM share mechanisms that contribute to their pathobiology. No comprehensive evaluation of the relationship between PE and PPCM exists.

methodsA systematic predetermined search strategy was performed in multiple databases to identify studies describing ≥3 women with PPCM. Prevalence rates of PE, hypertension, multiple gestations, and multiparity were pooled.

resultsData from 22 studies (n = 979) were included in this analysis. The pooled prevalence of 22% (95% confidence interval [CI]: 16% to 28%) was more than quadruple the 5% average worldwide background rate of PE in pregnancy (p < 0.001). There were no geographic or racial differences detected in the prevalence of PE in women with PPCM. The rates of hypertension during pregnancy (37% [95% CI: 29% to 45%]) and multiple gestations (9% [95% CI: 7% to 11%]) were also elevated.

conclusionsThe prevalence of PE, hypertensive disorders, and multiple gestations in women with PPCM is markedly higher than that in the general population. These findings support the concept of a shared pathogenesis between PE and PPCM and highlight the need for awareness of the overlap between these 2 diseases.

Indexed as

Hypertension, Pregnancy-InducedPeripartum PeriodPregnancy Complications, CardiovascularCardiomyopathiesFemaleHumansHypertensionPregnancyPregnancy, MultiplePrevalenceRacial GroupsantiangiogenicCIconfidence intervalleft ventricular ejection fractionLVEFPEperipartum cardiomyopathyPPCMpre-eclampsiapreeclampsiasoluble vascular endothelial growth factor receptor-1sVEGFR1

Identifiers

PMID24013055
PMCPMC3931606
OpenAlexW2129146354

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.