ReviewThe Journal of steroid biochemistry and molecular biology2014
Menopausal hot flashes: mechanisms, endocrinology, treatment.
Review in The Journal of steroid biochemistry and molecular biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers, 11 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
114 citing papers in PubMed, 11 syntheses or guidelines pooled it, 284 citations in OpenAlex.
- The effect of Oenothera biennis (Evening primrose) oil on inflammatory diseases: a systematic review of clinical trials.BMC complementary medicine and therapies · 2024Pooled it
- Pooled it
- The Effect ofInternational journal of community based nursing and midwifery · 2023Pooled it
- Magnitude of placebo response in clinical trials of paroxetine for vasomotor symptoms: a meta-analysis.Frontiers in psychiatry · 2023Pooled it
- The Effect of Vitamin E Supplementation in Postmenopausal Women-A Systematic Review.Nutrients · 2022Pooled it
- The Efficacy and Safety of Selective Serotonin Reuptake Inhibitors and Serotonin-Norepinephrine Reuptake Inhibitors in the Treatment of Menopausal Hot Flashes: A Systematic Review of Clinical Trials.Iranian journal of medical sciences · 2022Pooled it
- Clinical practice guideline of the Interamerican Society of Cardiology on primary prevention of cardiovascular disease in women.Archivos de cardiologia de Mexico · 2022Guideline
- Pooled it
- Evaluation of Clinical Meaningfulness of Red Clover (Nutrients · 2021Pooled it
- Effects of non-pharmacological supportive care for hot flushes in breast cancer: a meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2017Pooled it
- Effect of acupuncture on hot flush and menopause symptoms in breast cancer- A systematic review and meta-analysis.PloS one · 2017Pooled it
- Low-Dose Melatonin, Climacteric Symptoms and Sleep in Female Shift Workers: A Randomized Controlled Trial.Journal of pineal research · 2026Trial
- Effects of exercise training on vasomotor symptoms and quality of life in postmenopausal women: a randomized controlled trial.BMC women's health · 2025Trial
- Hot flashes and sleep disruption in a randomized trial in menopausal women.American journal of obstetrics and gynecology · 2025Trial
- Oral micronized progesterone for perimenopausal night sweats and hot flushes a Phase III Canada-wide randomized placebo-controlled 4 month trial.Scientific reports · 2023Trial
- Effects of stellate ganglion block on perimenopausal hot flashes: a randomized controlled trial.Frontiers in endocrinology · 2023Trial
- Trial
- Comparative effectiveness of electro-acupuncture versus gabapentin for sleep disturbances in breast cancer survivors with hot flashes: a randomized trial.Menopause (New York, N.Y.) · 2017Trial
- Combined Red Clover isoflavones and probiotics potently reduce menopausal vasomotor symptoms.PloS one · 2017Trial
- Acute stress alters autonomic modulation during sleep in women approaching menopause.Psychoneuroendocrinology · 2016Trial
54 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Hot flashes (HFs) are a rapid and exaggerated heat dissipation response, consisting of profuse sweating, peripheral vasodilation, and feelings of intense, internal heat. They are triggered by small elevations in core body temperature (Tc) acting within a greatly reduced thermoneutral zone, i.e., the Tc region between the upper (sweating) and lower (shivering) thresholds. This is due in part, but not entirely, to estrogen depletion at menopause. Elevated central sympathetic activation, mediated through α2-adrenergic receptors, is one factor responsible for narrowing of the thermoneutral zone. Procedures which reduce this activation, such as paced respiration and clonidine administration, ameliorate HFs as will peripheral cooling. HFs are responsible for some, but not all, of the sleep disturbance reported during menopause. Recent work calls into question the role of serotonin in HFs. This article is part of a Special Issue entitled 'Menopause'.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.