ArticleBiological psychiatry2013
Striatal-enriched protein tyrosine phosphatase-STEPs toward understanding chronic stress-induced activation of corticotrophin releasing factor neurons in the rat bed nucleus of the stria terminalis.
Article in Biological psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 58 citations in OpenAlex.
- Chronic Stress Alters Dorsal Bed Nucleus of Stria Terminalis Synaptic Neurotransmission in a Dravet Syndrome Mouse Model.bioRxiv : the preprint server for biology · 2026Article
- Stress History Modulates Corticotropin-Releasing Factor Neurons to Establish Resilience.Biological psychiatry global open science · 2026Article
- Activity of Corticotropin-Releasing Factor Neurons in the Bed Nucleus of the Stria Terminalis Reduces Anxiety-Potentiated Startle in Female Rats in an Estrous Phase-Dependent Manner.Biological psychiatry · 2026Article
- Vasopressin and oxytocin excite BNST neurons via oxytocin receptors, which reduce anxious arousal.Cell reports · 2025Article
- The role and mechanism of 5-HTDRN-BNST neural circuit in anxiety and fear lesions.Frontiers in neuroscience · 2024Review
- Chemogenetic activation of corticotropin-releasing factor-expressing neurons in the anterior bed nucleus of the stria terminalis reduces effortful motivation behaviors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Distinct populations of corticotropin-releasing factor (CRF) neurons mediate divergent yet complementary defensive behaviors in response to a threat.Neuropharmacology · 2023Review
- Sex differences in fear responses: Neural circuits.Neuropharmacology · 2023Review
- Chronic stress-induced synaptic changes to corticotropin-releasing factor-signaling in the bed nucleus of the stria terminalis.Frontiers in behavioral neuroscience · 2022Review
- Oxytocin excites BNST interneurons and inhibits BNST output neurons to the central amygdala.Neuropharmacology · 2021Article
- Extended amygdala circuits are differentially activated by context fear conditioning in male and female rats.Neurobiology of learning and memory · 2021Article
- Early-life stress alters affective behaviors in adult mice through persistent activation of CRH-BDNF signaling in the oval bed nucleus of the stria terminalis.Translational psychiatry · 2020Article
- Anxious to see you: Neuroendocrine mechanisms of social vigilance and anxiety during adolescence.The European journal of neuroscience · 2020Article
- Neuronal diversity of the amygdala and the bed nucleus of the stria terminalis.Handbook of behavioral neuroscience · 2020Article
- A novel GPR55-mediated satiety signal in the oval Bed Nucleus of the Stria Terminalis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Chronic stress induces cell type-selective transcriptomic and electrophysiological changes in the bed nucleus of the stria terminalis.Neuropharmacology · 2019Article
- Oxytocin receptors in the dorsolateral bed nucleus of the stria terminalis (BNST) bias fear learning toward temporally predictable cued fear.Translational psychiatry · 2019Article
- Sex-associated differences in excitability within the bed nucleus of the stria terminalis are reflective of cell-type.Neurobiology of stress · 2019Article
- Oxytocin facilitates adaptive fear and attenuates anxiety responses in animal models and human studies-potential interaction with the corticotropin-releasing factor (CRF) system in the bed nucleus of the stria terminalis (BNST).Cell and tissue research · 2019Review
- Conditioned Aversion and Neuroplasticity Induced by a Superagonist of Extrasynaptic GABAFrontiers in molecular neuroscience · 2019Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundStriatal-enriched protein tyrosine phosphatase (STEP) is a brain-specific protein tyrosine phosphatase that opposes the development of synaptic strengthening and the consolidation of fear memories. In contrast, stress facilitates fear memory formation, potentially by activating corticotrophin releasing factor (CRF) neurons in the anterolateral cell group of the bed nucleus of the stria terminalis (BNSTALG).
methodsHere, using dual-immunofluorescence, single-cell reverse transcriptase polymerase chain reaction, quantitative reverse transcriptase polymerase chain reaction, Western blot, and whole-cell patch-clamp electrophysiology, we examined the expression and role of STEP in regulating synaptic plasticity in rat BNSTALG neurons and its modulation by stress.
resultsStriatal-enriched protein tyrosine phosphatase was selectively expressed in CRF neurons in the oval nucleus of the BNSTALG. Following repeated restraint stress (RRS), animals displayed a significant increase in anxiety-like behavior, which was associated with a downregulation of STEP messenger RNA and protein expression in the BNSTALG, as well as selectively enhancing the magnitude of long-term potentiation (LTP) induced in Type III, putative CRF neurons. To determine if the changes in STEP expression following RRS were mechanistically related to LTP facilitation, we examined the effects of intracellular application of STEP on the induction of LTP. STEP completely blocked the RRS-induced facilitation of LTP in BNSTALG neurons.
conclusionsHence, STEP acts to buffer CRF neurons against excessive activation, while downregulation of STEP after chronic stress may result in pathologic activation of CRF neurons in the BNSTALG and contribute to prolonged states of anxiety. Thus, targeted manipulations of STEP activity might represent a novel treatment strategy for stress-induced anxiety disorders.
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