Evidence map›Paper›PMID 24012081›Full record

ReviewChild and adolescent psychiatric clinics of North America2013

Gray matter alterations in schizophrenia high-risk youth and early-onset schizophrenia: a review of structural MRI findings.

Benjamin K Brent, Heidi W Thermenos, Matcheri S Keshavan, Larry J Seidman

Abstract readReview
In one paragraph

Review in Child and adolescent psychiatric clinics of North America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
6.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 112 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Benjamin K BrentHarvard Medical School, Boston, MA 02115, USA; Division of Public Psychiatry, Massachusetts Mental Health Center, 75 Fenwood Road, Boston, MA 02115, USA; Department of Psychiatry, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA; Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address: bbrent@bidmc.harvard.edu.
Heidi W Thermenos
Matcheri S Keshavan
Larry J Seidman
Massachusetts General Hospital · USBeth Israel Deaconess Medical Center · USHarvard University · US

Funding

Administrative Supplement Harmonization of At Risk Multisite Observational Networks for Youth(HARMONY)U01MH081928 · NIMH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI STONE, WILLIAM SETH · 2008 to 2018
$7.1M
The Genetics of Endophenotypes and SchizophreniaR01MH065571 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BRAFF, DAVID L. · 2003 to 2013
$7.0M
Harvard Clinical and Translational Science Center (KL2)KL2RR025757 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$4.1M
Brain Function and Structure in Young Children at Familial Risk for SchizophreniaR21MH092840 · NIMH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI GABRIELI, JOHN, KESHAVAN, MATCHERI S. · 2012 to 2013
$482k
NCRR NIH HHS KL2 RR 025757NCRR NIH HHS KL2 RR025757NIMH NIH HHS L30 MH091727NIMH NIH HHS MH065571NIMH NIH HHS MH081928NIMH NIH HHS MH092840NIMH NIH HHS R01 MH065571NIMH NIH HHS R21 MH092840NIMH NIH HHS U01 MH081928PHS HHS 78113PHS HHS KO2 01180PHS HHS R01 64023
6 · The paper itself

Abstract

This article reviews the literature on structural magnetic resonance imaging findings in pediatric and young adult populations at clinical or genetic high-risk for schizophrenia and early-onset schizophrenia. The implications of this research are discussed for understanding the pathophysiology of schizophrenia and for early intervention strategies. The evidence linking brain structural changes in prepsychosis development and early-onset schizophrenia with disruptions of normal neurodevelopmental processes during childhood or adolescence is described. Future directions are outlined for research to address knowledge gaps regarding the neurobiological basis of brain structural abnormalities in schizophrenia and to improve the usefulness of these abnormalities for preventative interventions.

Indexed as

Disease ProgressionProdromal SymptomsSchizophrenic PsychologyAdolescentAdolescent DevelopmentAge of OnsetBrainChild DevelopmentCross-Sectional StudiesGenetic Predisposition to DiseaseHumansInfant, NewbornLongitudinal StudiesMagnetic Resonance ImagingModels, TheoreticalSchizophreniaChildhood-onset schizophreniaEarly-onset schizophreniaGenetic high-riskProdromeSchizophreniaStructural MRI

Identifiers

PMID24012081
PMCPMC3767930
OpenAlexW2212814050

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.