ArticleNeuron2013
Laminar and columnar development of barrel cortex relies on thalamocortical neurotransmission.
Article in Neuron, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers.
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Who cites it
96 citing papers in PubMed, 160 citations in OpenAlex.
- Cortical morphometric inverse divergence in attention-deficit/hyperactivity disorder correlates with cell-type-specific, laminar-specific and developmental transcriptomic signatures.Psychological medicine · 2026Article
- Astrocyte Store-Released Calcium Modulates Visual Cortex Synapse Development and Circuit Function.Research square · 2025Article
- Sensory modality-specific wiring of thalamocortical circuits.Nature reviews. Neuroscience · 2025Review
- Geometric constraints on the architecture of mammalian cortical connectomes.bioRxiv : the preprint server for biology · 2025Article
- Striatal output regulates the postnatal maturation of cortical circuits.Cell reports · 2025Article
- Pre-Sensory Spontaneous Activity Accelerates Coordinated Maturation of Synaptic Partners and Drives Transition to the Mature Physiological Phenotype.bioRxiv : the preprint server for biology · 2025Article
- Inducible NMDA receptor knockdown reveals a maintenance phase in dendritic refinement of barrel cortex neurons.iScience · 2025Article
- Human thalamocortical structural connectivity develops in line with a hierarchical axis of cortical plasticity.Nature neuroscience · 2025Article
- Translaminar synchronous neuronal activity is required for columnar synaptic strengthening in the mouse neocortex.Nature communications · 2025Article
- Regional patterns of human cortex development correlate with underlying neurobiology.Nature communications · 2024Article
- Regional patterns of human cortex development correlate with underlying neurobiology.bioRxiv : the preprint server for biology · 2024Article
- Making Ramón y Cajal proud: Development of cell identity and diversity in the cerebral cortex.Neuron · 2024Review
- A sensorimotor-association axis of thalamocortical connection development.bioRxiv : the preprint server for biology · 2024Article
- Spatiotemporal Mapping and Molecular Basis of Whole-brain Circuit Maturation.bioRxiv : the preprint server for biology · 2024Article
- Development and Evolution of Thalamocortical Connectivity.Cold Spring Harbor perspectives in biology · 2024Review
- Human neuronal maturation comes of age: cellular mechanisms and species differences.Nature reviews. Neuroscience · 2024Review
- Early-life maturation of the somatosensory cortex: sensory experience and beyond.Frontiers in neural circuits · 2024Review
- Activity-dependent dendrite patterning in the postnatal barrel cortex.Frontiers in neural circuits · 2024Review
- Article
- CUX1-related neurodevelopmental disorder: deep insights into phenotype-genotype spectrum and underlying pathology.European journal of human genetics : EJHG · 2023Article
36 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
A dynamic interplay between intrinsic regional molecular cues and extrinsic factors from the thalamus shape multiple features of early cortical development. It remains uncertain and controversial, however, whether the initial formation of cortical columns depends on neuronal activity, and there is little evidence that cortical lamination or neuronal differentiation is influenced by extrinsic activity. We examined the role of thalamic-derived factors in cortical development by selectively eliminating glutamatergic synaptic transmission from thalamocortical neurons in mice and found that eliminating thalamocortical neurotransmission prevented the formation of "barrel" columns in somatosensory cortex. Interestingly, based on cytoarchitectonic criteria and genetic markers, blocking thalamocortical neurotransmission also perturbed the development of superficial cortical lamina and the morphologic development of neurons. These experiments demonstrate that barrels and aspects of the layer-dependent pattern of cortical cytoarchitecture, gene expression, and neuronal differentiation depend on thalamocortical neurotransmission, extending the apparent influence of extrinsic, presumably activity-dependent factors, on cortical development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.