Evidence map›Paper›PMID 24011574›Full record

ReviewSeminars in nephrology2013

The genetics and epigenetics of kidney development.

Sanjeevkumar R Patel, Gregory R Dressler

Open access · greenAbstract readReview
In one paragraph

Review in Seminars in nephrology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 27 citations in OpenAlex.

  1. The Role of the PAX Genes in Renal Cell Carcinoma.International journal of molecular sciences · 2024
    Review
  2. Article
  3. Article
  4. Review
  5. Sexual Dimorphism of Corticosteroid Signaling during Kidney Development.International journal of molecular sciences · 2021
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Epigenetics in kidney development and renal disease.Translational research : the journal of laboratory and clinical medicine · 2015
    Review
  15. Kidney: polycystic kidney disease.Wiley interdisciplinary reviews. Developmental biology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Sanjeevkumar R PatelDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI.
Gregory R Dressler
University of Michigan–Ann Arbor · US

Funding

Research Supplement to Promote Diversity in Health Related ResearchR01DK054740 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DRESSLER, GREGORY R · 1999 to 2024
$9.0M
Epigenetic Regulation of Kidney DevelopmentR01DK073722 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DRESSLER, GREGORY R · 2006 to 2020
$4.6M
Mechanism of Gene Repression in the KidneyR01DK082409 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PATEL, SANJEEVKUMAR R · 2009 to 2013
$1.5M
NIDDK NIH HHS DK073722NIDDK NIH HHS DK082409NIDDK NIH HHS R01 DK054740NIDDK NIH HHS R01 DK073722NIDDK NIH HHS R01 DK082409
6 · The paper itself

Abstract

The development of the mammalian kidney has been studied at the genetic, biochemical, and cell biological level for more than 40 years. As such, detailed mechanisms governing early patterning, cell lineages, and inductive interactions have been well described. How genes interact to specify the renal epithelial cells of the nephrons and how this specification is relevant to maintaining normal renal function is discussed. Implicit in the development of the kidney are epigenetic mechanisms that mark renal cell types and connect certain developmental regulatory factors to chromatin modifications that control gene expression patterns and cellular physiology. In adults, such regulatory factors and their epigenetic pathways may function in regeneration and may be disturbed in disease processes.

Indexed as

Epigenesis, GeneticAnimalsBody PatterningCell LineageGene Expression RegulationHumansKidneyNephronsTRPP Cation ChannelsTRPP Cation Channelsepigeneticsintermediate mesodermKidney developmentnephrogenesis

Identifiers

PMID24011574
PMCPMC3767926
OpenAlexW2056281511

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.