Evidence map›Paper›PMID 24011541›Full record

ArticleNeurobiology of aging2014

Biological correlates of adult cognition: midlife in the United States (MIDUS).

Arun S Karlamangla, Dana Miller-Martinez, Margie E Lachman, Patricia A Tun, Brandon K Koretz, Teresa E Seeman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Personality and Cognitive Decline in Older Adults: Data From a Longitudinal Sample and Meta-Analysis.The journals of gerontology. Series B, Psychological sciences and social sciences · 2016
    Pooled it
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Arun S KarlamanglaUniversity of California at Los Angeles, Department of Medicine, Division of Geriatrics, Los Angeles, CA, USA. Electronic address: akarlamangla@mednet.ucla.edu.
Dana Miller-Martinez
Margie E Lachman
Patricia A Tun
Brandon K Koretz
Teresa E Seeman

Funding

STATISTICS COREP01AG020166 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI RYFF, CAROL D. · 2002 to 2015
$50.6M
ZDV &3TC NEVIRAPINE COMBINATION THERAPY IN HIV 1 INFECTED INFANTS &M01RR000865 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WASHINGTON, ARNOLD E. · 1985 to 2011
$43.4M
UCLA OLDER AMERICANS INDEPENDENCE CENTERP30AG028748 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2006 to 2017
$9.8M
Histories of Social Engagement and Cognitive FunctioningR01AG032271 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SEEMAN, TERESA E · 2009 to 2010
$999k
NCRR NIH HHS M01 RR000865NCRR NIH HHS M01-RR000865NIA NIH HHS 1R01 AG032271NIA NIH HHS 2P01 AG020166NIA NIH HHS 2P30-AG028748NIA NIH HHS P01 AG020166NIA NIH HHS P30 AG028748NIA NIH HHS R01 AG032271
6 · The paper itself

Abstract

Multiple biological processes are related to cognitive impairment in older adults, but their combined impact on cognition in midlife is not known. Using an array of measurements across key regulatory physiological systems and a state-of-the-art cognition battery that is sensitive to early changes, in a large, national sample of middle-aged and older adults, we examined the associations of individual biological systems and a combined, multi-system index, allostatic load, with cognitive performance. Allostatic load was strongly inversely associated with performance in both episodic memory and executive function. Of 7 biological systems, only the cardiovascular system was associated inversely with both; inflammation was associated inversely with episodic memory only, and glucose metabolism with executive function only. The associations of allostatic load with cognition were not different by age, suggesting that the implications of high allostatic load on cognitive functioning are not restricted to older adults. Findings suggest that a multi-system score, like allostatic load, may assist in the early identification of adults at increased risk for cognitive impairment.

Indexed as

AgedAllostasisCardiovascular Physiological PhenomenaCognitionCognitive DysfunctionEarly DiagnosisExecutive FunctionFemaleGlucoseHumansMaleMemoryMiddle AgedNeuropsychological TestsRiskUnited StatesGlucoseAdult cognitionAllostatic loadDysregulated physiologyInflammation

Identifiers

PMID24011541
PMCPMC3830604

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.