ArticleCell metabolism2013
K(ATP)-channel-dependent regulation of catecholaminergic neurons controls BAT sympathetic nerve activity and energy homeostasis.
Article in Cell metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Central noradrenaline transporter availability in highly obese, non-depressed individuals.European journal of nuclear medicine and molecular imaging · 2017Trial
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- Systemic Glucose Homeostasis Requires Pancreatic but Not Neuronal ATP-sensitive Potassium Channels.Function (Oxford, England) · 2025Article
- Integrating causal human genetics andFrontiers in molecular biosciences · 2025Article
- Astrocytic GLUT1 reduction paradoxically improves central and peripheral glucose homeostasis.Science advances · 2024Article
- Diversity of ancestral brainstem noradrenergic neurons across species and multiple biological factors.bioRxiv : the preprint server for biology · 2024Article
- The effects of ghrelin and LEAP-2 in energy homeostasis are modulated by thermoneutrality, high-fat diet and aging.Journal of endocrinological investigation · 2024Article
- Energy metabolism and syncope.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Article
- Neuronal modulation of brown adipose activity through perturbation of white adipocyte lipogenesis.Molecular metabolism · 2018Article
- Regulation of Chemerin and CMKLR1 Expression by Nutritional Status, Postnatal Development, and Gender.International journal of molecular sciences · 2018Article
- Loading and firing the brown adipocyte.Adipocyte · 2018Review
- Converging roles of ion channels, calcium, metabolic stress, and activity pattern of Substantia nigra dopaminergic neurons in health and Parkinson's disease.Journal of neurochemistry · 2016Review
- AgRP Neurons Control Systemic Insulin Sensitivity via Myostatin Expression in Brown Adipose Tissue.Cell · 2016Article
- Metabolic dysfunction in obstructive sleep apnea: A critical examination of underlying mechanisms.Sleep and biological rhythms · 2015Article
- Central nervous system regulation of brown adipose tissue.Comprehensive Physiology · 2014Review
- Central neural regulation of brown adipose tissue thermogenesis and energy expenditure.Cell metabolism · 2014Review
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
Abstract
Brown adipose tissue (BAT) is a critical regulator of glucose, lipid, and energy homeostasis, and its activity is tightly controlled by the sympathetic nervous system. However, the mechanisms underlying CNS-dependent control of BAT sympathetic nerve activity (SNA) are only partly understood. Here, we demonstrate that catecholaminergic neurons in the locus coeruleus (LC) adapt their firing frequency to extracellular glucose concentrations in a K(ATP)-channel-dependent manner. Inhibiting K(ATP)-channel-dependent control of neuronal activity via the expression of a variant K(ATP) channel in tyrosine-hydroxylase-expressing neurons and in neurons of the LC enhances diet-induced obesity in mice. Obesity results from decreased energy expenditure, lower steady-state BAT SNA, and an attenuated ability of centrally applied glucose to activate BAT SNA. This impairs the thermogenic transcriptional program of BAT. Collectively, our data reveal a role of K(ATP)-channel-dependent neuronal excitability in catecholaminergic neurons in maintaining thermogenic BAT sympathetic tone and energy homeostasis.
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