ArticleBMC infectious diseases2013
Genotypic and phenotypic analysis of diarrheagenic Escherichia coli strains isolated from Brazilian children living in low socioeconomic level communities.
Article in BMC infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Global incidence of human Shiga toxin-producing Escherichia coli infections and deaths: a systematic review and knowledge synthesis.Foodborne pathogens and disease · 2014Pooled it
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- Detection and assessment of fecal carriage of gastrointestinal pathogens in healthy community adults: a year-long study.BMC infectious diseases · 2026Article
- EnteroaggregativeEcoSal Plus · 2025Review
- High prevalence of enterotoxigenicFrontiers in microbiology · 2025Article
- Prevalence of DiarrhoeagenicMicroorganisms · 2023Article
- Epidemiology of Enteroaggregative, Enteropathogenic, and Shiga Toxin-Producing Escherichia coli Among Children Aged <5 Years in 3 Countries in Africa, 2015-2018: Vaccine Impact on Diarrhea in Africa (VIDA) Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Transposon mutagenesis of atypical enteroaggregativeFrontiers in cellular and infection microbiology · 2023Article
- Epidemiological investigations of diarrhea in children in Praia city, Cape Verde.Frontiers in microbiology · 2022Article
- Molecular Characterization and Antimicrobial Resistance of PathogenicJournal of tropical medicine · 2022Article
- Hybrid Atypical Enteropathogenic and ExtraintestinalPathogens (Basel, Switzerland) · 2021Article
- Improved Genomic Identification, Clustering, and Serotyping of Shiga Toxin-ProducingFrontiers in cellular and infection microbiology · 2021Article
- Genomic characterization of enteropathogenicThe veterinary quarterly · 2020Article
- Characterization and antibiotic resistance pattern of diffusely adherentNew microbes and new infections · 2020Article
- Low frequency of enterohemorrhagic, enteroinvasive and diffusely adherent Escherichia coli in children under 5 years in rural Mozambique: a case-control study.BMC infectious diseases · 2020Article
- High-resolution characterisation of ESBL/pAmpC-producing Escherichia coli isolated from the broiler production pyramid.Scientific reports · 2020Article
- Analysis of the Virulence Profile and Phenotypic Features of Typical and Atypical EnteroaggregativeFrontiers in cellular and infection microbiology · 2020Article
- Diarrheagenic Escherichia coli in Costa Rican children: a 9-year retrospective study.BMC research notes · 2019Article
- Shiga-Toxin ProducingMicroorganisms · 2019Review
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7 authors.
Funding
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Abstract
backgroundChildhood diarrheal diseases remain highly endemic in developing areas of Brazil. The importance of Escherichia coli among children with diarrhea in these areas was unknown. This study determined the prevalence of different E. coli categories in symptomatic and asymptomatic children from low socioeconomic level rural communities in southeastern Brazil.
methodsA total of 560 stool samples were collected from 141 children with diarrhea (< 10 years) and 419 apparently healthy controls who resided in 23 communities. E. coli isolates (n = 1943) were subjected to two multiplex PCRs developed for the detection of enteropathogenic E. coli (EPEC), enteroaggregative E. coli (EAEC), diffusely adherent E. coli (DAEC), enterotoxigenic E. coli (ETEC), enteroinvasive E. coli (EIEC), and Shiga toxin-producing E. coli (STEC). Strains were also examined for the presence of EPEC, EAEC, and DAEC by assays of adhesion to HEp-2 cells and by hybridization with specific DNA probes.
resultsDiarrheagenic E. coli strains were isolated from 253 (45.2%) children, and were associated with diarrhea in children aged < 5 years (p < 0.001). EAEC (20.9%), DAEC (11.6%), EPEC (9.3%) were the most frequent pathotypes, followed by ETEC (2.7%), EIEC (0.5%), and STEC (0.2%). Depending of the assay, EPEC, EAEC, and DAEC (collectively termed enteroadherent E. coli) strains were isolated in 45% to 56% of diarrhea cases, a significantly higher incidence than in controls (P < 0.05). Individually, only DAEC showed significant association with diarrhea (p < 0.05), particularly in children aged 2-5 years.
conclusionThis study indicates that enteroadherent E. coli is an important cause of diarrhea in children living in low socioeconomic level communities in southeastern Brazil. Our results reveal that the PCR1 assay is an excellent tool for the identification of EAEC and DAEC.
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