ArticleBiophysical journal2013
A stochastic model of calcium puffs based on single-channel data.
Article in Biophysical journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Large deviations of piecewise-deterministic Markov processes with application to stochastic calcium waves.Journal of mathematical biology · 2026Article
- Modeling the spatiotemporal properties of crosstalk between RyR-mediated and IPFrontiers in cell and developmental biology · 2026Article
- Stochastic model of IP3-induced Ca2+ spiking of HEK293 cells.PLoS computational biology · 2025Article
- Modeling traveling calcium waves in cellular structures.Journal of computational neuroscience · 2025Article
- A CaJournal of mathematical biology · 2025Article
- Modeling IPBiophysical journal · 2023Article
- Encoding, transmission, decoding, and specificity of calcium signals in plants.Journal of experimental botany · 2022Review
- Purinoreceptors and ectonucleotidases control ATP-induced calcium waveforms and calcium-dependent responses in microglia: Roles of P2 receptors and CD39 in ATP-stimulated microglia.Frontiers in physiology · 2022Article
- Highly localized intracellular CaeLife · 2021Article
- Stochastic reaction-diffusion modeling of calcium dynamics in 3D dendritic spines of Purkinje cells.Biophysical journal · 2021Article
- Calcium Dynamics and Water Transport in Salivary Acinar Cells.Bulletin of mathematical biology · 2021Review
- The native ORAI channel trio underlies the diversity of CaNature communications · 2020Article
- Disentangling astroglial physiology with a realistic cell model in silico.Nature communications · 2018Article
- Calcium as a signal integrator in developing epithelial tissues.Physical biology · 2018Review
- Analyzing optical imaging of CaCell calcium · 2017Article
- Mapping Interpuff Interval Distribution to the Properties of Inositol Trisphosphate Receptors.Biophysical journal · 2017Article
- The relative contributions of store-operated and voltage-gated CaThe Journal of physiology · 2017Article
- On the dynamical structure of calcium oscillations.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- A mathematical model of calcium dynamics in HSY cells.PLoS computational biology · 2017Article
- Functional Role of Intracellular Calcium Receptor Inositol 1,4,5-Trisphosphate Type 1 in Rat Hippocampus after Neonatal Anoxia.PloS one · 2017Article
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Calcium puffs are local transient Ca(2+) releases from internal Ca(2+) stores such as the endoplasmic reticulum or the sarcoplasmic reticulum. Such release occurs through a cluster of inositol 1,4,5-trisphosphate receptors (IP3Rs). Based on the IP3R model (which is determined by fitting to stationary single-channel data) and nonstationary single-channel data, we construct a new IP3R model that includes time-dependent rates of mode switches. A point-source model of Ca(2+) puffs is then constructed based on the new IP3R model and is solved by a hybrid Gillespie method with adaptive timing. Model results show that a relatively slow recovery of an IP3R from Ca(2+) inhibition is necessary to reproduce most of the experimental outcomes, especially the nonexponential interpuff interval distributions. The number of receptors in a cluster could be severely underestimated when the recovery is sufficiently slow. Furthermore, we find that, as the number of IP3Rs increases, the average duration of puffs initially increases but then becomes saturated, whereas the average decay time keeps increasing linearly. This gives rise to the observed asymmetric puff shape.
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