ArticleBiophysical journal2013
Cell optical density and molecular composition revealed by simultaneous multimodal label-free imaging.
Article in Biophysical journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Virtual Overlay Staining With Plasmonic Oligomer Metasurface.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Non-invasive detection of regulatory T cells with Raman spectroscopy.Scientific reports · 2024Article
- Label-free mid-infrared photothermal live-cell imaging beyond video rate.Light, science & applications · 2023Article
- Non-invasive monitoring of T cell differentiation through Raman spectroscopy.Scientific reports · 2023Article
- Introduction to Infrared and Raman-Based Biomedical Molecular Imaging and Comparison with Other Modalities.Molecules (Basel, Switzerland) · 2020Review
- Immune cell type, cell activation, and single cell heterogeneity revealed by label-free optical methods.Scientific reports · 2019Article
- Noninvasive detection of macrophage activation with single-cell resolution through machine learning.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Multimodal discrimination of immune cells using a combination of Raman spectroscopy and digital holographic microscopy.Scientific reports · 2017Article
- Review
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Authors and funding
3 authors.
Funding
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Abstract
We show how Raman imaging can be combined with independent but simultaneous phase measurements of unlabeled cells, with the resulting data providing information on how the light is retarded and/or scattered by molecules in the cell. We then show, for the first time to our knowledge, how the chemistry of the cell highlighted in the Raman information is related to the cell quantitative phase information revealed in digital holographic microscopy by quantifying how the two sets of spatial information are correlated. The results show that such a multimodal implementation is highly useful for the convenience of having video rate imaging of the cell during the entire Raman measurement time, allowing us to observe how the cell changes during Raman acquisition. More importantly, it also shows that the two sets of label-free data, which result from different scattering mechanisms, are complementary and can be used to interpret the composition and dynamics of the cell, where each mode supplies label-free information not available from the other mode.
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Registered trials
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