ArticleBiophysical journal2013
Quantifying cell-to-cell variation in power-law rheology.
Article in Biophysical journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 1 citations in OpenAlex.
- Mapping single-cell rheology of ascidian embryos in the cleavage stages using AFM.Biophysical journal · 2025Article
- Mechanical properties of epithelial cells in domes investigated using atomic force microscopy.Frontiers in cell and developmental biology · 2023Article
- Average Rheological Quantities of Cells in Monolayers.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Viscoelastic properties of suspended cells measured with shear flow deformation cytometry.eLife · 2022Article
- Review
- Article
- Pharmacological Alteration of Cellular Mechanical Properties in Pulmonary Arterial Smooth Muscle Cells of Idiopathic Pulmonary Arterial Hypertension.Cardiology research · 2021Article
- Rheology of rounded mammalian cells over continuous high-frequencies.Nature communications · 2021Article
- Cell nucleus as a microrheological probe to study the rheology of the cytoskeleton.Biophysical journal · 2021Article
- Spatiotemporal dynamics of single cell stiffness in the early developing ascidian chordate embryo.Communications biology · 2021Article
- Sensorless Self-Excited Vibrational Viscometer with Two Hopf Bifurcations Based on a Piezoelectric Device.Sensors (Basel, Switzerland) · 2021Article
- Environmentally controlled magnetic nano-tweezer for living cells and extracellular matrices.Scientific reports · 2020Article
- Increased stiffness and flow resistance of the inner wall of Schlemm's canal in glaucomatous human eyes.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- A distribution-based approach for determining lot sizes in the filling of human-induced pluripotent stem cells.Regenerative therapy · 2019Article
- Spontaneous Spatial Correlation of Elastic Modulus in Jammed Epithelial Monolayers Observed by AFM.Biophysical journal · 2019Article
- Probe Sensitivity to Cortical versus Intracellular Cytoskeletal Network Stiffness.Biophysical journal · 2019Article
- Computational modeling of single-cell mechanics and cytoskeletal mechanobiology.Wiley interdisciplinary reviews. Systems biology and medicine · 2018Review
- Quantitative Deformability Cytometry: Rapid, Calibrated Measurements of Cell Mechanical Properties.Biophysical journal · 2017Article
- Temporal Variation in Single-Cell Power-Law Rheology Spans the Ensemble Variation of Cell Population.Biophysical journal · 2017Article
- Unbiased High-Precision Cell Mechanical Measurements with Microconstrictions.Biophysical journal · 2017Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
Among individual cells of the same source and type, the complex shear modulus G(∗) exhibits a large log-normal distribution that is the result of spatial, temporal, and intrinsic variations. Such large distributions complicate the statistical evaluation of pharmacological treatments and the comparison of different cell states. However, little is known about the characteristic features of cell-to-cell variation. In this study, we investigated how this variation depends on the spatial location within the cell and on the actin filament cytoskeleton, the organization of which strongly influences cell mechanics. By mechanically probing fibroblasts arranged on a microarray, via atomic force microscopy, we observed that the standard deviation σ of G(∗) was significantly reduced among cells in which actin filaments were depolymerized. The parameter σ also exhibited a subcellular spatial dependence. Based on our findings regarding the frequency dependence of σ of the storage modulus G('), we proposed two types of cell-to-cell variation in G(') that arise from the purely elastic and the frequency-dependent components in terms of the soft glassy rheology model of cell deformability. We concluded that the latter inherent cell-to-cell variation can be reduced greatly by disrupting actin networks, by probing at locations within the cell nucleus boundaries distant from the cell center, and by measuring at high loading frequencies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.