ArticleBiomedical optics express2013
In vivo two-photon imaging of the mouse retina.
Article in Biomedical optics express, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed.
- Automated montaging and contrast stretching of adaptive optics ophthalmoscope images.Biomedical optics express · 2026Article
- Automated animal gimbal steering for retinal imaging and stimulation.Biomedical optics express · 2026Article
- Characterization of adeno-associated viral transduction of retinal ganglion cells in adult and old mice.Molecular therapy. Methods & clinical development · 2025Article
- Transpupillary in vivo two-photon imaging reveals enhanced surveillance of retinal microglia in diabetic mice.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Review
- Review
- Lipofuscin, Its Origin, Properties, and Contribution to Retinal Fluorescence as a Potential Biomarker of Oxidative Damage to the Retina.Antioxidants (Basel, Switzerland) · 2023Review
- Article
- Evolution of adaptive optics retinal imaging [Invited].Biomedical optics express · 2023Review
- Fluorescence Angiography with Dual Fluorescence for the Early Detection and Longitudinal Quantitation of Vascular Leakage in Retinopathy.Biomedicines · 2023Article
- Longitudinal in vivo CaProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Axonal architecture of the mouse inner retina revealed by second harmonic generation.PNAS nexus · 2022Article
- Non-invasive multimodal imaging of Diabetic Retinopathy: A survey on treatment methods and Nanotheranostics.Nanotheranostics · 2021Article
- Arrangement of the photoreceptor mosaic in a diabetic rat model imaged with multiphoton microscopy.Biomedical optics express · 2020Article
- Adaptive optics two-photon microscopy enables near-diffraction-limited and functional retinal imaging in vivo.Light, science & applications · 2020Article
- Adaptive optics in the mouse eye: wavefront sensing based vs. image-guided aberration correction.Biomedical optics express · 2019Article
- Non-invasive cellular-resolution retinal imaging with two-photon excited fluorescence.Biomedical optics express · 2019Article
- Recent trends in two-photon auto-fluorescence lifetime imaging (2P-FLIM) and its biomedical applications.Biomedical engineering letters · 2019Review
- Noninvasive Two-Photon Microscopy Imaging of Mouse Retina and Retinal Pigment Epithelium.Methods in molecular biology (Clifton, N.J.) · 2019Article
- All-optical recording and stimulation of retinal neurons in vivo in retinal degeneration mice.PloS one · 2018Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Though in vivo two-photon imaging has been demonstrated in non-human primates, improvements in the signal-to-noise ratio (SNR) would greatly improve its scientific utility. In this study, extrinsic fluorophores, expressed in otherwise transparent retinal ganglion cells, were imaged in the living mouse eye using a two-photon fluorescence adaptive optics scanning laser ophthalmoscope. We recorded two orders of magnitude greater signal levels from extrinsically labeled cells relative to previous work done in two-photon autofluorescence imaging of primates. Features as small as single dendrites in various layers of the retina could be resolved and predictions are made about the feasibility of measuring functional response from cells. In the future, two-photon imaging in the intact eye may allow us to monitor the function of retinal cell classes with infrared light that minimally excites the visual response.
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Registered trials
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