Evidence map›Paper›PMID 24009991›Full record

ArticleBiomedical optics express2013

Depth resolved detection of lipid using spectroscopic optical coherence tomography.

Christine P Fleming, Jocelyn Eckert, Elkan F Halpern, Joseph A Gardecki, Guillermo J Tearney

Abstract read
In one paragraph

Article in Biomedical optics express, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Christine P FlemingColumbia University, Department of Electrical Engineering, New York, New York, USA.
Jocelyn Eckert
Elkan F Halpern
Joseph A Gardecki
Guillermo J Tearney

Funding

Chemical analysis of coronary atherosclerosis in patientsR01HL093717 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI TEARNEY, GUILLERMO J · 2008 to 2011
$3.3M
NHLBI NIH HHS R01 HL093717
6 · The paper itself

Abstract

Optical frequency domain imaging (OFDI) can identify key components related to plaque vulnerability but can suffer from artifacts that could prevent accurate identification of lipid rich regions. In this paper, we present a model of depth resolved spectral analysis of OFDI data for improved detection of lipid. A quadratic Discriminant analysis model was developed based on phantom compositions known chemical mixtures and applied to a tissue phantom of a lipid-rich plaque. We demonstrate that a combined spectral and attenuation model can be used to predict the presence of lipid in OFDI images.

Indexed as

(110.4500) Optical coherence tomography(170.1580) Chemometrics(170.6510) Spectroscopy, tissue diagnostics

Identifiers

PMID24009991
PMCPMC3756567

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.