ArticlePloS one2013
A longitudinal study of the impact of social deprivation and disease severity on employment status in the UK cystic fibrosis population.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Socioeconomic circumstances and respiratory function from childhood to early adulthood: a systematic review and meta-analysis.BMJ open · 2019Pooled it
- Empirical estimate for the indirect healthcare costs of sickle cell disease from a retrospective cohort study in England between 2007 and 2019.BMC health services research · 2026Article
- Psychosocial and mental health in cystic fibrosis in the modern era of care: time to evolve.BMJ open respiratory research · 2025Review
- Themes associated with uncollected paediatric prescriptions at a large tertiary children's hospital: a retrospective, observational study.BMJ paediatrics open · 2024Observational
- Aiming to Improve Equity in Pulmonary Health: Cystic Fibrosis.Clinics in chest medicine · 2023Review
- Work participation in adults with rare genetic diseases - a scoping review.BMC public health · 2023Article
- Educational achievements of children aged 10-11 years with cystic fibrosis. A data linkage study in Wales.International journal of population data science · 2022Article
- Cystic Fibrosis Lung Disease Modifiers and Their Relevance in the New Era of Precision Medicine.Genes · 2021Review
- Influences of environmental exposures on individuals living with cystic fibrosis.Expert review of respiratory medicine · 2020Review
- Poverty and child health in the UK: using evidence for action.Archives of disease in childhood · 2016Review
- Children and young adults with CF in the USA have better lung function compared with the UK.Thorax · 2015Article
- Birth data accessibility via primary care health records to classify health status in a multi-ethnic population of children: an observational study.NPJ primary care respiratory medicine · 2015Observational
- Low socioeconomic status is associated with worse lung function in the Danish cystic fibrosis population.The European respiratory journal · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPeople with Cystic Fibrosis (CF) in the UK and elsewhere are increasingly surviving into adulthood, yet there is little research on the employment consequences of having CF. We investigated, for the first time in a UK-wide cohort, longitudinal employment status, and its association with deprivation, disease severity, and time in hospital.
methodsWe did a longitudinal registry study of adults with CF in the UK aged 20 to 40 (3458 people with 15,572 observations between 1996 and 2010), using mixed effects models.
resultsAround 50% of adults with CF were in employment. Male sex, higher lung function and body mass index, and less time in hospital were associated with improved employment chances. All other things being equal, being in the most deprived quintile was associated with a reduction of employment prevalence of 17.6 percentage points compared to the prevalence in the least deprived quintile. Having poor lung function was associated with a reduced employment prevalence of 7.2 percentage points compared to the prevalence for people with relatively good lung function. Acting synergistically, deprivation modifies the effect of lung function on employment chances - poor lung function in the least deprived group was associated with a 3 percentage point reduction in employment chances, while poor lung function in the most deprived quintile was associated with a 7.7 point reduction in employment chances.
conclusionsGreater deprivation, disease severity, and time in hospital are all associated with employment chances in adults with CF. Furthermore, our analysis suggests that deprivation amplifies the harmful association of disease severity on employment. Future studies should focus on understanding and mitigating the barriers to employment faced by people with CF.
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