ArticlePloS one2013
Moving domain computational fluid dynamics to interface with an embryonic model of cardiac morphogenesis.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 69 citations in OpenAlex.
- Longitudinal Live Imaging-Derived 4D Hemodynamics and Dynamic Tissue Mechanics Across Outflow Tract Morphogenesis.Annals of biomedical engineering · 2026Article
- Non-Newtonian blood rheology significantly alters hemodynamic predictions during cardiac looping: a computational study.Frontiers in bioengineering and biotechnology · 2026Article
- A fluid-structure interaction model of the zebrafish aortic valve.Journal of biomechanics · 2025Article
- Hemodynamics During Development and Postnatal Life.Advances in experimental medicine and biology · 2024Review
- Highly specific and non-invasive imaging of Piezo1-dependent activity across scales using GenEPi.Nature communications · 2023Article
- Recent advances in quantifying the mechanobiology of cardiac development via computational modeling.Current opinion in biomedical engineering · 2023Article
- Effect of Blood Flow on Cardiac Morphogenesis and Formation of Congenital Heart Defects.Journal of cardiovascular development and disease · 2022Review
- In vivo acoustic manipulation of microparticles in zebrafish embryos.Science advances · 2022Article
- Computational simulations of the 4D micro-circulatory network in zebrafish tail amputation and regeneration.Journal of the Royal Society, Interface · 2022Article
- Article
- Haemodynamic dependence of mechano-genetic evolution of the cardiovascular system in Japanese medaka.Journal of the Royal Society, Interface · 2021Article
- A hybrid of light-field and light-sheet imaging to study myocardial function and intracardiac blood flow during zebrafish development.PLoS computational biology · 2021Article
- Computational Modeling of Blood Flow Hemodynamics for Biomechanical Investigation of Cardiac Development and Disease.Journal of cardiovascular development and disease · 2021Review
- Endothelial mechanotransduction in cardiovascular development and regeneration: emerging approaches and animal models.Current topics in membranes · 2021Review
- Automatic Segmentation and Cardiac Mechanics Analysis of Evolving Zebrafish Using Deep Learning.Frontiers in cardiovascular medicine · 2021Article
- Correcting anisotropic intensity in light sheet images using dehazing and image morphology.APL bioengineering · 2020Article
- Imaging of the immune system - towards a subcellular and molecular understanding.Journal of cell science · 2020Review
- Organ Dynamics and Hemodynamic of the Whole HH25 Avian Embryonic Heart, Revealed by Ultrasound Biomicroscopy, Boundary Tracking, and Flow Simulations.Scientific reports · 2019Article
- Contractile and hemodynamic forces coordinate Notch1b-mediated outflow tract valve formation.JCI insight · 2019Article
- Vortex Dynamics in Trabeculated Embryonic Ventricles.Journal of cardiovascular development and disease · 2019Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
Peristaltic contraction of the embryonic heart tube produces time- and spatial-varying wall shear stress (WSS) and pressure gradients (∇P) across the atrioventricular (AV) canal. Zebrafish (Danio rerio) are a genetically tractable system to investigate cardiac morphogenesis. The use of Tg(fli1a:EGFP) (y1) transgenic embryos allowed for delineation and two-dimensional reconstruction of the endocardium. This time-varying wall motion was then prescribed in a two-dimensional moving domain computational fluid dynamics (CFD) model, providing new insights into spatial and temporal variations in WSS and ∇P during cardiac development. The CFD simulations were validated with particle image velocimetry (PIV) across the atrioventricular (AV) canal, revealing an increase in both velocities and heart rates, but a decrease in the duration of atrial systole from early to later stages. At 20-30 hours post fertilization (hpf), simulation results revealed bidirectional WSS across the AV canal in the heart tube in response to peristaltic motion of the wall. At 40-50 hpf, the tube structure undergoes cardiac looping, accompanied by a nearly 3-fold increase in WSS magnitude. At 110-120 hpf, distinct AV valve, atrium, ventricle, and bulbus arteriosus form, accompanied by incremental increases in both WSS magnitude and ∇P, but a decrease in bi-directional flow. Laminar flow develops across the AV canal at 20-30 hpf, and persists at 110-120 hpf. Reynolds numbers at the AV canal increase from 0.07±0.03 at 20-30 hpf to 0.23±0.07 at 110-120 hpf (p< 0.05, n=6), whereas Womersley numbers remain relatively unchanged from 0.11 to 0.13. Our moving domain simulations highlights hemodynamic changes in relation to cardiac morphogenesis; thereby, providing a 2-D quantitative approach to complement imaging analysis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.