ArticleBiomicrofluidics2012
In vitro electrical-stimulated wound-healing chip for studying electric field-assisted wound-healing process.
Article in Biomicrofluidics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Pooled it
- SCHEPHERD: A modular, programmable, direct current platform to control cell behavior.Science advances · 2026Article
- SCHEPHERD: A universal platform for high-throughput, high-resolution, and programmable control of cell behavior through bioelectric stimulation.bioRxiv : the preprint server for biology · 2025Article
- Organoids/organs-on-chips towards biomimetic human artificial skin.Burns & trauma · 2025Review
- Cell Migration Assays and Their Application to Wound Healing Assays-A Critical Review.Micromachines · 2024Review
- A bioelectronic device for electric field treatment of wounds reduces inflammation in an in vivo mouse model.PloS one · 2024Article
- Skin models of cutaneous toxicity, transdermal transport and wound repair.Burns & trauma · 2023Review
- Pulsed Electromagnetic Field Therapy and Direct Current Electric Field Modulation Promote the Migration of Fibroblast-like Synoviocytes to Accelerate Cartilage Repair In Vitro.Applied sciences (Basel, Switzerland) · 2022Article
- Short-term bioelectric stimulation of collective cell migration in tissues reprograms long-term supracellular dynamics.PNAS nexus · 2022Article
- Come together: On-chip bioelectric wound closure.Biosensors & bioelectronics · 2021Article
- Probing Antimicrobial Halloysite/Biopolymer Composites with Electron Microscopy: Advantages and Limitations.Polymers · 2021Review
- Electric Factors in Wound Healing.Advances in wound care · 2021Article
- Dielectrophoresis Prototypic Polystyrene Particle Synchronization toward Alive Keratinocyte Cells for Rapid Chronic Wound Healing.Sensors (Basel, Switzerland) · 2021Article
- Electrotaxis-on-Chip to Quantify Neutrophil Migration Towards Electrochemical Gradients.Frontiers in immunology · 2021Article
- Percutaneous Application of Galvanic Current in Rodents Reverses Signs of Myofascial Trigger Points.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- A microfluidics-based wound-healing assay for studying the effects of shear stresses, wound widths, and chemicals on the wound-healing process.Scientific reports · 2019Article
- A flow-based microfluidic device for spatially quantifying intracellular calcium ion activity during cellular electrotaxis.Biomicrofluidics · 2019Article
- Use Microfluidic Chips to Study the Phototaxis of Lung Cancer Cells.International journal of molecular sciences · 2019Article
- Effects of Substrate-Coating Materials on the Wound-Healing Process.Materials (Basel, Switzerland) · 2019Article
- Multi-Organs-on-Chips: Towards Long-Term Biomedical Investigations.Molecules (Basel, Switzerland) · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The wound-healing assay is an easy and economical way to quantify cell migration under diverse stimuli. Traditional assays such as scratch assays and barrier assays are widely and commonly used, but neither of them can represent the complicated condition when a wound occurs. It has been suggested that wound-healing is related to electric fields, which were found to regulate wound re-epithelialization. As a wound occurs, the disruption of epithelial barrier short-circuits the trans-epithelial potential and then a lateral endogenous electric field is created. This field has been proved invitro as an important cue for guiding the migration of fibroblasts, macrophages, and keratinocytes, a phenomenon termed electrotaxis or galvanotaxis. In this paper, we report a microfluidic electrical-stimulated wound-healing chip (ESWHC) integrating electric field with a modified barrier assay. This chip was used to study the migration of fibroblasts under different conditions such as serum, electric field, and wound-healing-promoting drugs. We successfully demonstrate the feasibility of ESWHC to effectively and quantitatively study cell migration during wound-healing process, and therefore this chip could be useful in drug discovery and drug safety tests.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.