ArticleBiomicrofluidics2012
Electrotaxis of oral squamous cell carcinoma cells in a multiple-electric-field chip with uniform flow field.
Article in Biomicrofluidics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Glioblastoma U-87 cell electrotaxis is hindered by doxycycline with a concomitant reduction in the matrix metallopeptidase-9 expression.Biochemistry and biophysics reports · 2024Article
- Brain stimulation-on-a-chip: a neuromodulation platform for brain slices.Lab on a chip · 2023Article
- Bioelectronic microfluidic wound healing: a platform for investigating direct current stimulation of injured cell collectives.Lab on a chip · 2023Article
- Voltage-gated ion channels mediate the electrotaxis of glioblastoma cells in a hybrid PMMA/PDMS microdevice.APL bioengineering · 2020Article
- Biomedical applications of electrical stimulation.Cellular and molecular life sciences : CMLS · 2020Review
- Doxycycline inhibits electric field-induced migration of non-small cell lung cancer (NSCLC) cells.Scientific reports · 2019Article
- Glioblastoma adhesion in a quick-fit hybrid microdevice.Biomedical microdevices · 2019Article
- Studying Electrotaxis in Microfluidic Devices.Sensors (Basel, Switzerland) · 2017Review
- Designing Microfluidic Devices for Studying Cellular Responses Under Single or Coexisting Chemical/Electrical/Shear Stress Stimuli.Journal of visualized experiments : JoVE · 2016Article
- Uniform electric field generation in circular multi-well culture plates using polymeric inserts.Scientific reports · 2016Article
- Electrotaxis Studies of Lung Cancer Cells using a Multichannel Dual-electric-field Microfluidic Chip.Journal of visualized experiments : JoVE · 2015Article
- Correlation between cell migration and reactive oxygen species under electric field stimulation.Biomicrofluidics · 2015Article
- Collective migration exhibits greater sensitivity but slower dynamics of alignment to applied electric fields.Cellular and molecular bioengineering · 2015Article
- Galvanotactic control of collective cell migration in epithelial monolayers.Nature materials · 2014Article
- The construction of an interfacial valve-based microfluidic chip for thermotaxis evaluation of human sperm.Biomicrofluidics · 2014Article
- Recent Developments in Electrotaxis Assays.Advances in wound care · 2014Review
- Evaluation of EGFR and RTK signaling in the electrotaxis of lung adenocarcinoma cells under direct-current electric field stimulation.PloS one · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report a new design of microfluidic chip (Multiple electric Field with Uniform Flow chip, MFUF chip) to create multiple electric field strengths (EFSs) while providing a uniform flow field simultaneously. MFUF chip was fabricated from poly-methyl methacrylates (PMMA) substrates by using CO2 laser micromachining. A microfluidic network with interconnecting segments was utilized to de-couple the flow field and the electric field (EF). Using our special design, different EFSs were obtained in channel segments that had an identical cross-section and therefore a uniform flow field. Four electric fields with EFS ratio of 7.9:2.8:1:0 were obtained with flow velocity variation of only 7.8% CV (coefficient of variation). Possible biological effect of shear force can therefore be avoided. Cell behavior under three EFSs and the control condition, where there is no EF, was observed in a single experiment. We validated MFUF chip performance using lung adenocarcinoma cell lines and then used the chip to study the electrotaxis of HSC-3, an oral squamous cell carcinoma cell line. The MFUF chip has high throughput capability for studying the EF-induced cell behavior under various EFSs, including the control condition (EFS = 0).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.