ReviewFrontiers in immunology2013
Adenine Dinucleotide Second Messengers and T-lymphocyte Calcium Signaling.
Review in Frontiers in immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- NAMPT activity plays a key role in driving autoimmune processes that mediate beta-cell death and type 1 diabetes development in mice.Cell death & disease · 2026Article
- Progressive Elevation of Store-Operated Calcium Entry-Associated Regulatory Factor (SARAF) and Calcium Pathway Dysregulation in Multiple Sclerosis.International journal of molecular sciences · 2025Article
- Biological Functions and Therapeutic Potential of NADCancers · 2024Review
- Nicotinamide N-Methyltransferase (NNMT): A New Hope for Treating Aging and Age-Related Conditions.Metabolites · 2024Review
- CD38-RyR2 axis-mediated signaling impedes CD8Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- CD38 promotes hematopoietic stem cell dormancy.PLoS biology · 2024Article
- The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update.Advances in nutrition (Bethesda, Md.) · 2023Review
- NADCells · 2022Review
- Article
- The role of CD38 in HIV infection.AIDS research and therapy · 2021Review
- NADNature reviews. Molecular cell biology · 2021Review
- The Identification of a Novel Calcium-Dependent Link Between NADFrontiers in molecular biosciences · 2021Article
- TRPM2 Is Not Required for T-Cell Activation and Differentiation.Frontiers in immunology · 2021Article
- The N-terminal domain in TRPM2 channel is a conserved nucleotide binding site.The Journal of general physiology · 2020Article
- Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel.eLife · 2019Article
- Article
- CD38 Expression in a Subset of Memory T Cells Is Independent of Cell Cycling as a Correlate of HIV Disease Progression.Disease markers · 2016Article
- CD38 is expressed on inflammatory cells of the intestine and promotes intestinal inflammation.PloS one · 2015Article
- Ion channels in innate and adaptive immunity.Annual review of immunology · 2015Review
- Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calcium signaling is a universal signal transduction mechanism in animal and plant cells. In mammalian T-lymphocytes calcium signaling is essential for activation and re-activation and thus important for a functional immune response. Since many years it has been known that both calcium release from intracellular stores and calcium entry via plasma membrane calcium channels are involved in shaping spatio-temporal calcium signals. Second messengers derived from the adenine dinucleotides NAD and NADP have been implicated in T cell calcium signaling. Nicotinic acid adenine dinucleotide phosphate (NAADP) acts as a very early second messenger upon T cell receptor/CD3 engagement, while cyclic ADP-ribose (cADPR) is mainly involved in sustained partial depletion of the endoplasmic reticulum by stimulating calcium release via ryanodine receptors. Finally, adenosine diphosphoribose (ADPR) a breakdown product of both NAD and cADPR activates a plasma membrane cation channel termed TRPM2 thereby facilitating calcium (and sodium) entry into T cells. Receptor-mediated formation, metabolism, and mode of action of these novel second messengers in T-lymphocytes will be reviewed.
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