ArticleFrontiers in human neuroscience2013
Oxytocin and socioemotional aging: Current knowledge and future trends.
Article in Frontiers in human neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
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Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Tri-Phasic Model ofOxytocin (TRIO): A systematic conceptual review of oxytocin-related ERP research.Biological psychology · 2020Pooled it
- Chronic oxytocin administration as a tool for investigation and treatment: A cross-disciplinary systematic review.Neuroscience and biobehavioral reviews · 2020Pooled it
- Effects of four-week intranasal oxytocin administration on large-scale brain networks in older adults.Neuropharmacology · 2024Trial
- Age-dependent effects of oxytocin in brain regions enriched with oxytocin receptors.Psychoneuroendocrinology · 2024Trial
- Four-week intranasal oxytocin administration reduces attachment avoidance in older women.Hormones and behavior · 2023Trial
- Intranasal oxytocin modulates the salience network in aging.NeuroImage · 2022Trial
- Oxytocin alters patterns of brain activity and amygdalar connectivity by age during dynamic facial emotion identification.Neurobiology of aging · 2019Trial
- Early life stress modulates amygdala-prefrontal functional connectivity: implications for oxytocin effects.Human brain mapping · 2014Trial
- Oxytocin as regulator of stress and inflammation in aging.Neuroscience and biobehavioral reviews · 2026Review
- Oxytocin, Vasopressin and Stress: A Hormetic Perspective.Current issues in molecular biology · 2025Review
- The dynamic relationship of brain-derived neurotrophic factor and oxytocin: Introducing the concept of neurosocial plasticity.Neuroprotection (Chichester, England) · 2025Review
- Article
- Differential temporal decline of cerebral oxytocin and μ-opioid receptor density during the aging process in mice.The European journal of neuroscience · 2024Article
- Aging leads to sex-dependent effects on pair bonding and increased number of oxytocin-producing neurons in monogamous prairie voles.Hormones and behavior · 2024Article
- Oxytocin pathway gene variation and corticostriatal resting-state functional connectivity.Comprehensive psychoneuroendocrinology · 2024Article
- Postpartum Oxytocin Treatment via the Mother Reprograms Long-Term Behavioral Disorders Induced by Early Life Stress on the Plasma and Brain Metabolome in the Rat.International journal of molecular sciences · 2024Article
- Oxytocin: A developmental journey.Comprehensive psychoneuroendocrinology · 2023Review
- Neuroimaging of social motivation during winning and losing: Associations with social anhedonia across the psychosis spectrum.Neuropsychologia · 2023Article
- Effects of age on face perception: Reduced eye region discrimination ability but intact holistic processing.Psychology and aging · 2023Article
- DNA methylation of the oxytocin receptor interacts with age to impact neural response to social stimuli.Frontiers in aging neuroscience · 2023Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
The oxytocin (OT) system is involved in various aspects of social cognition and prosocial behavior. Specifically, OT has been examined in the context of social memory, emotion recognition, cooperation, trust, empathy, and bonding, and-though evidence is somewhat mixed-intranasal OT appears to benefit aspects of socioemotional functioning. However, most of the extant data on aging and OT is from animal research and human OT research has focused largely on young adults. As such, though we know that various socioemotional capacities change with age, we know little about whether age-related changes in the OT system may underlie age-related differences in socioemotional functioning. In this review, we take a genetic-neuro-behavioral approach and evaluate current evidence on age-related changes in the OT system as well as the putative effects of these alterations on age-related socioemotional functioning. Looking forward, we identify informational gaps and propose an Age-Related Genetic, Neurobiological, Sociobehavioral Model of Oxytocin (AGeNeS-OT model) which may structure and inform investigations into aging-related genetic, neural, and sociocognitive processes related to OT. As an exemplar of the use of the model, we report exploratory data suggesting differences in socioemotional processing associated with genetic variation in the oxytocin receptor gene (OXTR) in samples of young and older adults. Information gained from this arena has translational potential in depression, social stress, and anxiety-all of which have high relevance in aging-and may contribute to reducing social isolation and improving well-being of individuals across the lifespan.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.