ReviewFrontiers in cellular neuroscience2013
Are vesicular neurotransmitter transporters potential treatment targets for temporal lobe epilepsy?
Review in Frontiers in cellular neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 63 citations in OpenAlex.
- Audiogenic Kindling Stimulation Fails to Induce Cerebral Overexpression of P-Glycoprotein and Limbic Crises in the GASH/Sal Model of Epilepsy.International journal of molecular sciences · 2026Article
- Temporal Dynamics of tsRNA Regulation Mark an Abrupt Transition After Epileptogenesis.Journal of neurochemistry · 2025Article
- Phylogenetic and Structural Analyses of Vesicular Glutamate Transporters.Molecular neurobiology · 2025Article
- A new method for isolation and purification of fusion-competent inhibitory synaptic vesicles.Current research in physiology · 2024Article
- Preferential pruning of inhibitory synapses by microglia contributes to alteration of the balance between excitatory and inhibitory synapses in the hippocampus in temporal lobe epilepsy.CNS neuroscience & therapeutics · 2023Article
- Investigating the mechanism of antiepileptogenic effect of apigenin in kainate temporal lobe epilepsy: possible role of mTOR.Experimental brain research · 2023Article
- Neuroprotective Effect of Exogenous Galectin-1 in Status Epilepticus.Molecular neurobiology · 2022Article
- Insight into carbon quantum dot-vesicles interactions: role of functional groups.RSC advances · 2022Article
- The role of peptidyl-prolyl isomerase Pin1 in neuronal signaling in epilepsy.Frontiers in molecular neuroscience · 2022Review
- Localization, proteomics, and metabolite profiling reveal a putative vesicular transporter for UDP-glucose.eLife · 2021Article
- The Pin1-CaMKII-AMPA Receptor Axis Regulates Epileptic Susceptibility.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- The Role of Phospholipase C in GABAergic Inhibition and Its Relevance to Epilepsy.International journal of molecular sciences · 2021Review
- Modulation of Glucose Availability and Effects of Hypo- and Hyperglycemia on Status Epilepticus: What We Do Not Know Yet?Molecular neurobiology · 2021Review
- The autism/neuroprotection-linked ADNP/NAP regulate the excitatory glutamatergic synapse.Translational psychiatry · 2019Article
- Physiology of Astroglia.Physiological reviews · 2018Review
- Sleep-Dependent Structural Synaptic Plasticity of Inhibitory Synapses in the Dendrites of Hypocretin/Orexin Neurons.Molecular neurobiology · 2017Article
- Down-regulation of Pin1 in Temporal Lobe Epilepsy Patients and Mouse Model.Neurochemical research · 2017Article
- Neurochemical Markers in the Mammalian Brain: Structure, Roles in Synaptic Communication, and Pharmacological Relevance.Current medicinal chemistry · 2017Review
- NR4A1 Knockdown Suppresses Seizure Activity by Regulating Surface Expression of NR2B.Scientific reports · 2016Article
- Dorsal horn neurons release extracellular ATP in a VNUT-dependent manner that underlies neuropathic pain.Nature communications · 2016Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The vesicular neurotransmitter transporters (VNTs) are small proteins responsible for packing synaptic vesicles with neurotransmitters thereby determining the amount of neurotransmitter released per vesicle through fusion in both neurons and glial cells. Each transporter subtype was classically seen as a specific neuronal marker of the respective nerve cells containing that particular neurotransmitter or structurally related neurotransmitters. More recently, however, it has become apparent that common neurotransmitters can also act as co-transmitters, adding complexity to neurotransmitter release and suggesting intriguing roles for VNTs therein. We will first describe the current knowledge on vesicular glutamate transporters (VGLUT1/2/3), the vesicular excitatory amino acid transporter (VEAT), the vesicular nucleotide transporter (VNUT), vesicular monoamine transporters (VMAT1/2), the vesicular acetylcholine transporter (VAChT) and the vesicular γ-aminobutyric acid (GABA) transporter (VGAT) in the brain. We will focus on evidence regarding transgenic mice with disruptions in VNTs in different models of seizures and epilepsy. We will also describe the known alterations and reorganizations in the expression levels of these VNTs in rodent models for temporal lobe epilepsy (TLE) and in human tissue resected for epilepsy surgery. Finally, we will discuss perspectives on opportunities and challenges for VNTs as targets for possible future epilepsy therapies.
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