ArticleFrontiers in neuroscience2013
Central CRF neurons are not created equal: phenotypic differences in CRF-containing neurons of the rat paraventricular hypothalamus and the bed nucleus of the stria terminalis.
Article in Frontiers in neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 113 papers.
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Who cites it
113 citing papers in PubMed, 167 citations in OpenAlex.
- Regulation of amygdala and dopamine system in naïve and chronic alcohol states.Alcohol (Fayetteville, N.Y.) · 2026Article
- Chronic Stress Alters Dorsal Bed Nucleus of Stria Terminalis Synaptic Neurotransmission in a Dravet Syndrome Mouse Model.bioRxiv : the preprint server for biology · 2026Article
- Selective and differential roles of PVHNature communications · 2026Article
- Central neurons encode interleukin-1β signals and mediate stress-induced inflammation.The Journal of experimental medicine · 2026Article
- Stress History Modulates Corticotropin-Releasing Factor Neurons to Establish Resilience.Biological psychiatry global open science · 2026Article
- Activity of Corticotropin-Releasing Factor Neurons in the Bed Nucleus of the Stria Terminalis Reduces Anxiety-Potentiated Startle in Female Rats in an Estrous Phase-Dependent Manner.Biological psychiatry · 2026Article
- Central autonomic network dysfunction in Stroke-Heart Syndrome: mechanistic roles of the insula and limbic system.Frontiers in neuroscience · 2026Review
- Corticotropin-releasing factor neurons in the bed nucleus of the stria terminalis modulate avoidance behaviors and feeding.Frontiers in neuroscience · 2026Article
- Disentangling the effects of corticotrophin releasing factor and GABA release from the bed nucleus of the stria terminalis on ethanol self-administration in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Complexity of the Hypothalamic Oxytocin System and its Involvement in Brain Functions and Diseases.Neuroscience bulletin · 2025Review
- Vasopressin and oxytocin excite BNST neurons via oxytocin receptors, which reduce anxious arousal.Cell reports · 2025Article
- Extended amygdala corticotropin-releasing hormone neurons regulate sexually dimorphic changes in pair bond formation following social defeat in prairie voles (Microtus ochrogaster).Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Extended amygdala corticotropin-releasing hormone neurons regulate sexually dimorphic changes in pair bond formation following social defeat in prairie voles (bioRxiv : the preprint server for biology · 2024Article
- Corticotropin releasing factor alters the functional diversity of accumbal cholinergic interneurons.Journal of neurophysiology · 2024Article
- Hyperexcitation of ovBNST CRF neurons during stress contributes to female-biased expression of anxiety-like avoidance behaviors.Science advances · 2024Article
- Case report: Non-linear evolution of oxytocin informs YBOCS changes post-DBS of the bed nucleus of the stria terminalis for treatment resistant OCD.Frontiers in psychiatry · 2024Article
- The regulative role and mechanism of BNST in anxiety disorder.Frontiers in psychiatry · 2024Review
- Chemogenetic activation of corticotropin-releasing factor-expressing neurons in the anterior bed nucleus of the stria terminalis reduces effortful motivation behaviors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Detection, processing and reinforcement of social cues: regulation by the oxytocin system.Nature reviews. Neuroscience · 2023Review
- Disentangling the effects of Corticotrophin Releasing Factor and GABA release from the ventral bed nucleus of the stria terminalis on ethanol self-administration in mice.bioRxiv : the preprint server for biology · 2023Article
53 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
Corticotrophin-releasing factor (CRF) plays a key role in initiating many of the endocrine, autonomic, and behavioral responses to stress. CRF-containing neurons of the paraventricular nucleus of the hypothalamus (PVN) are classically involved in regulating endocrine function through activation of the stress axis. However, CRF is also thought to play a critical role in mediating anxiety-like responses to environmental stressors, and dysfunction of the CRF system in extra-hypothalamic brain regions, like the bed nucleus of stria terminalis (BNST), has been linked to the etiology of many psychiatric disorders including anxiety and depression. Thus, although CRF neurons of the PVN and BNST share a common neuropeptide phenotype, they may represent two functionally diverse neuronal populations. Here, we employed dual-immunofluorescence, single-cell RT-PCR, and electrophysiological techniques to further examine this question and report that CRF neurons of the PVN and BNST are fundamentally different such that PVN CRF neurons are glutamatergic, whereas BNST CRF neurons are GABAergic. Moreover, these two neuronal populations can be further distinguished based on their electrophysiological properties, their co-expression of peptide neurotransmitters such as oxytocin and arginine-vasopressin, and their cognate receptors. Our results suggest that CRF neurons in the PVN and the BNST would not only differ in their response to local neurotransmitter release, but also in their action on downstream target structures.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.