ArticlePLoS genetics2013
A nuclear calcium-sensing pathway is critical for gene regulation and salt stress tolerance in Arabidopsis.
Article in PLoS genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.
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Who cites it
34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- Uncovering core regulators of multi-abiotic stress adaptation in Arabidopsis thaliana through integrative meta-analysis and machine learning with RT-qPCR validation.Scientific reports · 2026Pooled it
- Pooled it
- Abiotic Stress in Crop Production.International journal of molecular sciences · 2023Pooled it
- Phosphorylation of VpCAMTA3 by VpCDPK13 enhances cold tolerance in grapevine.Horticulture research · 2026Article
- Salinity survival: molecular mechanisms and adaptive strategies in plants.Frontiers in plant science · 2025Review
- Emerging applications of gene editing technologies for the development of climate-resilient crops.Frontiers in genome editing · 2025Review
- Calcium signaling-mediated transcriptional reprogramming during abiotic stress response in plants.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Review
- The RNA-binding protein MdHYL1 modulates cold tolerance and disease resistance in apple.Plant physiology · 2023Article
- RcbHLH59-RcPRs module enhances salinity stress tolerance by balancing NaHorticulture research · 2023Article
- The positive feedback regulatory loop of miR160-Auxin Response Factor 17-HYPONASTIC LEAVES 1 mediates drought tolerance in apple trees.Plant physiology · 2022Article
- Enhancing growth and salinity stress tolerance of date palm usingFrontiers in plant science · 2022Article
- Systematic Analysis of bHLH Transcription Factors in Cassava Uncovers Their Roles in Postharvest Physiological Deterioration and Cyanogenic Glycosides Biosynthesis.Frontiers in plant science · 2022Article
- Molecular dissection of maize seedling salt tolerance using a genome-wide association analysis method.Plant biotechnology journal · 2021Article
- Basic Helix-Loop-Helix (bHLH) Transcription Factors Regulate a Wide Range of Functions in Arabidopsis.International journal of molecular sciences · 2021Review
- Generation of GCaMP6s-Expressing Zebrafish to Monitor Spatiotemporal Dynamics of Calcium Signaling Elicited by Heat Stress.International journal of molecular sciences · 2021Article
- Review
- Understanding salt tolerance mechanism using transcriptome profiling and de novo assembly of wild tomato Solanum chilense.Scientific reports · 2020Article
- Phase separation of Arabidopsis EMB1579 controls transcription, mRNA splicing, and development.PLoS biology · 2020Article
- Ribosome assembly factor Adenylate Kinase 6 maintains cell proliferation and cell size homeostasis during root growth.The New phytologist · 2020Article
- ATBS1-INTERACTING FACTOR 2 negatively regulates dark- and brassinosteroid-induced leaf senescence through interactions with INDUCER OF CBF EXPRESSION 1.Journal of experimental botany · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Salt stress is an important environmental factor that significantly limits crop productivity worldwide. Studies on responses of plants to salt stress in recent years have identified novel signaling pathways and have been at the forefront of plant stress biology and plant biology in general. Thus far, research on salt stress in plants has been focused on cytoplasmic signaling pathways. In this study, we discovered a nuclear calcium-sensing and signaling pathway that is critical for salt stress tolerance in the reference plant Arabidopsis. Through a forward genetic screen, we found a nuclear-localized calcium-binding protein, RSA1 (SHORT ROOT IN SALT MEDIUM 1), which is required for salt tolerance, and identified its interacting partner, RITF1, a bHLH transcription factor. We show that RSA1 and RITF1 regulate the transcription of several genes involved in the detoxification of reactive oxygen species generated by salt stress and that they also regulate the SOS1 gene that encodes a plasma membrane Na(+)/H(+) antiporter essential for salt tolerance. Together, our results suggest the existence of a novel nuclear calcium-sensing and -signaling pathway that is important for gene regulation and salt stress tolerance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.