ArticlePLoS genetics2013
Dynamic rewiring of the Drosophila retinal determination network switches its function from selector to differentiation.
Article in PLoS genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Modulating the levels and activity of the retinal determination network is sufficient to induce the specification of distinct tissue fates in Drosophila.Development (Cambridge, England) · 2025Article
- Comparative transcriptomic analysis primarily explores the molecular mechanism of compound eye formation in Neocaridina denticulata sinensis.BMC genomics · 2024Article
- A single cell genomics atlas of the Drosophila larval eye reveals distinct photoreceptor developmental timelines.Nature communications · 2023Article
- Single cell RNA sequencing of the adult Drosophila eye reveals distinct clusters and novel marker genes for all major cell types.Communications biology · 2022Article
- Human eye conditions: insights from the fly eye.Human genetics · 2019Review
- N-Cadherin Orchestrates Self-Organization of Neurons within a Columnar Unit in theThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Novel approach to quantitative spatial gene expression uncovers genetic stochasticity in the developing Drosophila eye.Evolution & development · 2019Article
- Integrative genomic analysis reveals novel regulatory mechanisms of eyeless during Drosophila eye development.Nucleic acids research · 2018Article
- Article
- MicroRNA-552 promotes tumor cell proliferation and migration by directly targeting DACH1 via the Wnt/β-catenin signaling pathway in colorectal cancer.Oncology letters · 2017Article
- Antagonistic regulation of the second mitotic wave by Eyes absent-Sine oculis and Combgap coordinates proliferation and specification in theDevelopment (Cambridge, England) · 2017Article
- Master regulators in development: Views from the Drosophila retinal determination and mammalian pluripotency gene networks.Developmental biology · 2017Review
- Retinal Expression of the Drosophila eyes absent Gene Is Controlled by Several Cooperatively Acting Cis-regulatory Elements.PLoS genetics · 2016Article
- Conditional knockout of retinal determination genes in differentiating cells in Drosophila.The FEBS journal · 2016Article
- Retinal determination genes coordinate neuroepithelial specification and neurogenesis modes in the Drosophila optic lobe.Development (Cambridge, England) · 2016Article
- Identification of novel direct targets of Drosophila Sine oculis and Eyes absent by integration of genome-wide data sets.Developmental biology · 2016Article
- Distinct Biochemical Activities of Eyes absent During Drosophila Eye Development.Scientific reports · 2016Article
- DACH1 inhibits lung adenocarcinoma invasion and tumor growth by repressing CXCL5 signaling.Oncotarget · 2015Article
- Eye selector logic for a coordinated cell cycle exit.PLoS genetics · 2015Article
- DACH1 inhibits cyclin D1 expression, cellular proliferation and tumor growth of renal cancer cells.Journal of hematology & oncology · 2014Article
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6 authors.
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Abstract
Organ development is directed by selector gene networks. Eye development in the fruit fly Drosophila melanogaster is driven by the highly conserved selector gene network referred to as the "retinal determination gene network," composed of approximately 20 factors, whose core comprises twin of eyeless (toy), eyeless (ey), sine oculis (so), dachshund (dac), and eyes absent (eya). These genes encode transcriptional regulators that are each necessary for normal eye development, and sufficient to direct ectopic eye development when misexpressed. While it is well documented that the downstream genes so, eya, and dac are necessary not only during early growth and determination stages but also during the differentiation phase of retinal development, it remains unknown how the retinal determination gene network terminates its functions in determination and begins to promote differentiation. Here, we identify a switch in the regulation of ey by the downstream retinal determination genes, which is essential for the transition from determination to differentiation. We found that central to the transition is a switch from positive regulation of ey transcription to negative regulation and that both types of regulation require so. Our results suggest a model in which the retinal determination gene network is rewired to end the growth and determination stage of eye development and trigger terminal differentiation. We conclude that changes in the regulatory relationships among members of the retinal determination gene network are a driving force for key transitions in retinal development.
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