ArticlePLoS genetics2013
The relative contribution of proximal 5' flanking sequence and microsatellite variation on brain vasopressin 1a receptor (Avpr1a) gene expression and behavior.
Article in PLoS genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 50 citations in OpenAlex.
- A yeast recombination system recapitulates the length polymorphism of a microsatellite implicated in human social behavior.NAR molecular medicine · 2026Article
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- Stay social, stay young: a bioanthropological outlook on the processes linking sociality and ageing.GeroScience · 2025Review
- Canine hyper-sociability structural variants associated with altered three-dimensional chromatin state.BMC genomics · 2024Article
- Association between arginine vasopressin receptor 1A (Proceedings. Biological sciences · 2023Article
- Modulation of social behavior by distinct vasopressin sources.Frontiers in endocrinology · 2023Review
- Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities.Endocrinology · 2022Review
- Nine Levels of Explanation : A Proposed Expansion of Tinbergen's Four-Level Framework for Understanding the Causes of Behavior.Human nature (Hawthorne, N.Y.) · 2021Article
- A Neuroscientist's Guide to the Vole.Current protocols · 2021Article
- Opposing effects of antibiotics and germ-free status on neuropeptide systems involved in social behaviour and pain regulation.BMC neuroscience · 2020Article
- Culture of Neurospheres Derived from the Neurogenic Niches in Adult Prairie Voles.Journal of visualized experiments : JoVE · 2020Article
- AVPR1A variation is linked to gray matter covariation in the social brain network of chimpanzees.Genes, brain, and behavior · 2020Article
- Correlation between miRNA target site polymorphisms in the 3' UTR ofBioscience reports · 2019Article
- Prairie Voles as a Model for Understanding the Genetic and Epigenetic Regulation of Attachment Behaviors.ACS chemical neuroscience · 2018Review
- The effects of transcription and recombination on mutational dynamics of short tandem repeats.Nucleic acids research · 2018Article
- Stabilizing selection on microsatellite allele length at arginine vasopressin 1a receptor and oxytocin receptor loci.Proceedings. Biological sciences · 2017Article
- Functional Mechanisms of Microsatellite DNA in Eukaryotic Genomes.Genome biology and evolution · 2017Review
- SVA retrotransposons as potential modulators of neuropeptide gene expression.Neuropeptides · 2017Review
- Balancing selection maintains polymorphisms at neurogenetic loci in field experiments.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Microsatellite polymorphisms associated with human behavioural and psychological phenotypes including a gene-environment interaction.BMC medical genetics · 2017Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Certain genes exhibit notable diversity in their expression patterns both within and between species. One such gene is the vasopressin receptor 1a gene (Avpr1a), which exhibits striking differences in neural expression patterns that are responsible for mediating differences in vasopressin-mediated social behaviors. The genomic mechanisms that contribute to these remarkable differences in expression are not well understood. Previous work has suggested that both the proximal 5' flanking region and a polymorphic microsatellite element within that region of the vole Avpr1a gene are associated with variation in V1a receptor (V1aR) distribution and behavior, but neither has been causally linked. Using homologous recombination in mice, we reveal the modest contribution of proximal 5' flanking sequences to species differences in V1aR distribution, and confirm that variation in V1aR distribution impacts stress-coping in the forced swim test. We also demonstrate that the vole Avpr1a microsatellite structure contributes to Avpr1a expression in the amygdala, thalamus, and hippocampus, mirroring a subset of the inter- and intra-species differences observed in central V1aR patterns in voles. This is the first direct evidence that polymorphic microsatellite elements near behaviorally relevant genes can contribute to diversity in brain gene expression profiles, providing a mechanism for generating behavioral diversity both at the individual and species level. However, our results suggest that many features of species-specific expression patterns are mediated by elements outside of the immediate 5' flanking region of the gene.
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Registered trials
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