ArticlePLoS genetics2013
Species and population level molecular profiling reveals cryptic recombination and emergent asymmetry in the dimorphic mating locus of C. reinhardtii.
Article in PLoS genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 54 citations in OpenAlex.
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- Whole-genome sequencing analysis of volvocine green algae reveals the molecular genetic basis for the diversity and evolution of sex.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2024Review
- Comparative transcriptome analysis of dioecious floral development in Trachycarpus fortunei using Illumina and PacBio SMRT sequencing.BMC plant biology · 2023Article
- A conserved RWP-RK transcription factor VSR1 controls gametic differentiation in volvocine algae.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- The Chlamydomonas Genome Project, version 6: Reference assemblies for mating-type plus and minus strains reveal extensive structural mutation in the laboratory.The Plant cell · 2023Article
- Sex-linked deubiquitinase establishes uniparental transmission of chloroplast DNA.Nature communications · 2022Article
- Switching it up: algal insights into sexual transitions.Plant reproduction · 2021Article
- Evolutionary Genomics of Sex-Related Chromosomes at the Base of the Green Lineage.Genome biology and evolution · 2021Article
- Comparative genomics of Chlamydomonas.The Plant cell · 2021Article
- HAP2-Mediated Gamete Fusion: Lessons From the World of Unicellular Eukaryotes.Frontiers in cell and developmental biology · 2021Review
- Convergent evolution of linked mating-type loci in basidiomycete fungi.PLoS genetics · 2019Article
- UV Chromosomes and Haploid Sexual Systems.Trends in plant science · 2018Review
- Evolutionary divergence of the sex-determining geneDevelopment (Cambridge, England) · 2018Article
- Morphology, taxonomy and mating-type loci in natural populations of Volvox carteri in Taiwan.Botanical studies · 2018Article
- Anisogamy evolved with a reduced sex-determining region in volvocine green algae.Communications biology · 2018Article
- Genomic structure and evolution of the mating type locus in the green seaweed Ulva partita.Scientific reports · 2017Article
- Gene Regulatory Networks for the Haploid-to-Diploid Transition ofPlant physiology · 2017Article
- Widespread maintenance of genome heterozygosity in Schmidtea mediterranea.Nature ecology & evolution · 2016Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Heteromorphic sex-determining regions or mating-type loci can contain large regions of non-recombining sequence where selection operates under different constraints than in freely recombining autosomal regions. Detailed studies of these non-recombining regions can provide insights into how genes are gained and lost, and how genetic isolation is maintained between mating haplotypes or sex chromosomes. The Chlamydomonas reinhardtii mating-type locus (MT) is a complex polygenic region characterized by sequence rearrangements and suppressed recombination between its two haplotypes, MT+ and MT-. We used new sequence information to redefine the genetic contents of MT and found repeated translocations from autosomes as well as sexually controlled expression patterns for several newly identified genes. We examined sequence diversity of MT genes from wild isolates of C. reinhardtii to investigate the impacts of recombination suppression. Our population data revealed two previously unreported types of genetic exchange in Chlamydomonas MT--gene conversion in the rearranged domains, and crossover exchanges in flanking domains--both of which contribute to maintenance of genetic homogeneity between haplotypes. To investigate the cause of blocked recombination in MT we assessed recombination rates in crosses where the parents were homozygous at MT. While normal recombination was restored in MT+ ×MT+ crosses, it was still suppressed in MT- ×MT- crosses. These data revealed an underlying asymmetry in the two MT haplotypes and suggest that sequence rearrangements are insufficient to fully account for recombination suppression. Together our findings reveal new evolutionary dynamics for mating loci and have implications for the evolution of heteromorphic sex chromosomes and other non-recombining genomic regions.
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