ReviewBiologics : targets & therapy2013
Clinical utility of asthma biomarkers: from bench to bedside.
Review in Biologics : targets & therapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04755829 (Breath Test to Predict Breast Cancer and Outcome of Mammography), which is not on this map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Breath Test to Predict Breast Cancer and Outcome of Mammography
Who cites it
40 citing papers in PubMed, 87 citations in OpenAlex.
- Novel Serum Biomarkers for Patients with Allergic Asthma Phenotype.Biomedicines · 2024Article
- Reliability of Total Serum IgE Levels to Define Type 2 High and Low Asthma Phenotypes.Journal of clinical medicine · 2023Article
- Phenotype overlap in the natural history of asthma.European respiratory review : an official journal of the European Respiratory Society · 2023Review
- Effect of VEGF Stimulation on CD11b Receptor on Peripheral Eosinophils in Asthmatics.International journal of molecular sciences · 2023Article
- Periostin as an important biomarker of inflammatory phenotype T2 in Brazilian asthma patients.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2023Article
- Precision Medicine in Asthma Therapy.Handbook of experimental pharmacology · 2023Article
- Influence of vascular endothelial growth factor on neutrophil activation in asthmatics.Postepy dermatologii i alergologii · 2022Article
- Clinical and functional characteristics of OSA in children with comorbid asthma treated by leukotriene receptor antagonist: A descriptive study.Frontiers in neurology · 2022Article
- Critical evaluation of asthma biomarkers in clinical practice.Frontiers in medicine · 2022Review
- Diagnostic Accuracy of Liquid Biomarkers in Airway Diseases: Toward Point-of-Care Applications.Frontiers in medicine · 2022Review
- Article
- Comparing Patient Characteristics, Clinical Outcomes, and Biomarkers of Severe Asthma Patients in Taiwan.Biomedicines · 2021Article
- Investigating the relationship between particulate matter and inflammatory biomarkers of exhaled breath condensate and blood in healthy young adults.Scientific reports · 2021Article
- Recent Insights into the Management of Inflammation in Asthma.Journal of inflammation research · 2021Review
- Status and prospects: personalized treatment and biomarker for airway remodeling in asthma.Journal of thoracic disease · 2020Review
- Asthma and Corticosteroid Responses in Childhood and Adult Asthma.Clinics in chest medicine · 2019Review
- Demonstrating the application of Raman spectroscopy together with chemometric technique for screening of asthma disease.Biomedical optics express · 2019Article
- Association of plasma soluble CD14 level with asthma severity in adults: a case control study in China.Respiratory research · 2019Article
- Discriminatory Molecular Biomarkers of Allergic and Nonallergic Asthma and Its Severity.Frontiers in immunology · 2019Article
- Novel eosinophilic gene expression networks associated with IgE in two distinct asthma populations.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Asthma is a chronic disease characterized by airway inflammation, bronchial hyperresponsiveness, and recurrent episodes of reversible airway obstruction. The disease is very heterogeneous in onset, course, and response to treatment, and seems to encompass a broad collection of heterogeneous disease subtypes with different underlying pathophysiological mechanisms. There is a strong need for easily interpreted clinical biomarkers to assess the nature and severity of the disease. Currently available biomarkers for clinical practice - for example markers in bronchial lavage, bronchial biopsies, sputum, or fraction of exhaled nitric oxide (FeNO) - are limited due to invasiveness or lack of specificity. The assessment of markers in peripheral blood might be a good alternative to study airway inflammation more specifically, compared to FeNO, and in a less invasive manner, compared to bronchoalveolar lavage, biopsies, or sputum induction. In addition, promising novel biomarkers are discovered in the field of breath metabolomics (eg, volatile organic compounds) and (pharmaco)genomics. Biomarker research in asthma is increasingly shifting from the assessment of the value of single biomarkers to multidimensional approaches in which the clinical value of a combination of various markers is studied. This could eventually lead to the development of a clinically applicable algorithm composed of various markers and clinical features to phenotype asthma and improve diagnosis and asthma management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.