Observational studyAndrology2013
Semen parameters in fertile US men: the Study for Future Families.
Observational study in Andrology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Racial/Ethnic differences in male reproductive health: a systematic review and meta-analysis of semen parameters and hormonal profiles in the United States.International journal of impotence research · 2025Pooled it
- Temporal trends in sperm count: a systematic review and meta-regression analysis.Human reproduction update · 2017Pooled it
- Racial differences in male fertility parameters in 2,996 men examined for infertility in a single center.Arab journal of urology · 2025Article
- A Review of Semen Analysis: Updates From the WHO Sixth Edition Manual and Advances in Male Fertility Assessment.Cureus · 2024Review
- Geographic Differences in Semen Quality among a Cohort of American Men Using Mail-in Sperm Testing Kits.The world journal of men's health · 2023Article
- The impact of socioeconomic status on bulk semen parameters, fertility treatment, and fertility outcomes in a cohort of subfertile men.Fertility and sterility · 2023Article
- Occupation and Semen Parameters in a Cohort of Fertile Men.Journal of occupational and environmental medicine · 2022Article
- Spatiotemporal trends in human semen quality.Nature reviews. Urology · 2022Review
- Androgen Receptor Gene CAG Repeat Length Varies and Affects Semen Quality in an Ethnic-Specific Fashion in Young Men from Russia.International journal of molecular sciences · 2022Article
- Basic Phenotyping of Male Fertility from 2019 to 2020 at the Human Sperm Bank of Fudan University.Phenomics (Cham, Switzerland) · 2022Article
- Metal(loid)s and human semen quality: The LIFE Study.Reproductive toxicology (Elmsford, N.Y.) · 2021Article
- Pervasive structural racism in environmental epidemiology.Environmental health : a global access science source · 2021Article
- Does semen analysis testing reveal disparities?Nature reviews. Urology · 2021Article
- Regional and ethnic differences in semen quality and reproductive hormones in Russia: A Siberian population-based cohort study of young men.Andrology · 2021Article
- Whole-Exome Sequencing Analysis of Human Semen Quality in Russian Multiethnic Population.Frontiers in genetics · 2021Article
- The effect of ethnicity on semen analysis and hormones in the infertile patient.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2020Article
- Semen and reproductive hormone parameters in fertile men with and without varicocele.Andrologia · 2019Article
- Low total motile sperm in transgender women seeking hormone therapy.Journal of assisted reproduction and genetics · 2019Article
- Small RNAs in Rat Sperm Are a Predictive and Sensitive Biomarker of Exposure to the Testicular Toxicant Ethylene Glycol Monomethyl Ether.Toxicological sciences : an official journal of the Society of Toxicology · 2019Article
- Do pregnancy rates differ with intra-uterine insemination when different combinations of semen analysis parameters are abnormal?Journal of the Turkish German Gynecological Association · 2018Article
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Authors and funding
11 authors at 6 institutions in 1 country.
Funding
Abstract
Establishing reference norms for semen parameters in fertile men is important for accurate assessment, counselling and treatment of men with male factor infertility. Identifying temporal or geographic variability in semen quality also requires accurate measurement of semen parameters in well-characterized, defined populations of men. The Study for Future Families (SFF) recruited men who were partners of pregnant women attending prenatal clinics in Los Angeles CA, Minneapolis MN, Columbia MO, New York City NY and Iowa City IA. Semen samples were collected on site from 763 men (73% White, 15% Hispanic/Latino, 7% Black and 5% Asian or other ethnic group) using strict quality control and well-defined protocols. Semen volume (by weight), sperm concentration (hemacytometer) and sperm motility were measured at each centre. Sperm morphology (both WHO, 1999 strict and WHO, 1987) was determined at a central laboratory. Mean abstinence was 3.2 days. Mean (median; 5th-95th percentile) values were: semen volume, 3.9 (3.7; 1.5-6.8) mL; sperm concentration, 60 (67; 12-192) × 10(6) /mL; total sperm count 209 (240; 32-763) × 10(6) ; % motile, 51 (52; 28-67) %; and total motile sperm count, 104 (128; 14-395) × 10(6) respectively. Values for sperm morphology were 11 (10; 3-20) % and 57 (59; 38-72) % normal forms for WHO (1999) (strict) and WHO (1987) criteria respectively. Black men had significantly lower semen volume, sperm concentration and total motile sperm counts than White and Hispanic/Latino men. Semen parameters were marginally higher in men who achieved pregnancy more quickly but differences were small and not statistically significant. The SFF provides robust estimates of semen parameters in fertile men living in five different geographic locations in the US. Fertile men display wide variation in all of the semen parameters traditionally used to assess fertility potential.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.