Evidence map›Paper›PMID 24009073›Full record

ArticleStatistics in medicine2014

A Bayesian approach to joint analysis of multivariate longitudinal data and parametric accelerated failure time.

Sheng Luo

Open access · bronzeAbstract read
In one paragraph

Article in Statistics in medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Sheng LuoDivision of Biostatistics, University of Texas School of Public Health, 1200 Pressler St., Houston, TX 77030, U.S.A.
The University of Texas Health Science Center at Houston · US

Funding

Supplemental Funding to the NET PD StudiesU01NS043128 · NINDS · UNIVERSITY OF ROCHESTER · PI KIEBURTZ, KARL D. · 2001 to 2014
$24.2M
Parkinson's Disease Clinical Trial: Statistical CenterU01NS043127 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LUO, SHENG · 2001 to 2015
$8.0M
Center for Clinical and Translational Sciences (CCTS)KL2TR000370 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MCPHERSON, DAVID D · 2012 to 2016
$4.3M
NCATS NIH HHS KL2 TR000370NINDS NIH HHS U01 NS043127NINDS NIH HHS U01NS043127NINDS NIH HHS U01 NS043128NINDS NIH HHS U01NS43128
6 · The paper itself

Abstract

Impairment caused by Parkinson's disease (PD) is multidimensional (e.g., sensoria, functions, and cognition) and progressive. Its multidimensional nature precludes a single outcome to measure disease progression. Clinical trials of PD use multiple categorical and continuous longitudinal outcomes to assess the treatment effects on overall improvement. A terminal event such as death or dropout can stop the follow-up process. Moreover, the time to the terminal event may be dependent on the multivariate longitudinal measurements. In this article, we consider a joint random-effects model for the correlated outcomes. A multilevel item response theory model is used for the multivariate longitudinal outcomes and a parametric accelerated failure time model is used for the failure time because of the violation of proportional hazard assumption. These two models are linked via random effects. The Bayesian inference via MCMC is implemented in 'BUGS' language. Our proposed method is evaluated by a simulation study and is applied to DATATOP study, a motivating clinical trial to determine if deprenyl slows the progression of PD.

Indexed as

Bayes TheoremModels, StatisticalMultivariate AnalysisComputer SimulationDisease ProgressionDrug Therapy, CombinationHumansLongitudinal StudiesMarkov ChainsMonte Carlo MethodParkinson DiseaseRandomized Controlled Trials as TopicSelegilineTocopherolsSelegilineTocopherolsclinical trialfailure timeitem response theorylatent variableMarkov chain Monte Carlo

Identifiers

PMID24009073
PMCPMC3947121
OpenAlexW2132424742

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.