Evidence map›Paper›PMID 24009032›Full record

ReviewWiley interdisciplinary reviews. Developmental biology

From molecules to mastication: the development and evolution of teeth.

Andrew H Jheon, Kerstin Seidel, Brian Biehs, Ophir D Klein

Abstract readReview
In one paragraph

Review in Wiley interdisciplinary reviews. Developmental biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. International journal of molecular sciences · 2025
    Article
  5. Article
  6. Prespecified dental mesenchymal cells for the making of a tooth.International journal of oral science · 2025
    Article
  7. Review
  8. Challenges of Studying Amelogenesis in Gene-Targeted Mouse Models.International journal of molecular sciences · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. The anatomy, neurophysiology, and cellular mechanisms of intradental sensation.Frontiers in pain research (Lausanne, Switzerland) · 2024
    Review
  14. Review
  15. Article
  16. Article
  17. Tooth Diversity Underpins Future Biomimetic Replications.Biomimetics (Basel, Switzerland) · 2023
    Review
  18. The conundrum of pharyngeal teeth origin: the role of germ layers, pouches, and gill slits.Biological reviews of the Cambridge Philosophical Society · 2022
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Andrew H JheonDepartment of Orofacial Sciences and Program in Craniofacial and Mesenchymal Biology, University of California San Francisco, San Francisco, CA, USA.
Kerstin Seidel
Brian Biehs
Ophir D Klein

Funding

An evolutionary-developmental approach to stem cells using teeth as a modelDP2OD007191 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KLEIN, OPHIR D · 2010 to 2010
$2.3M
The role of Bmi1 in regulation of dental stem cellsR01DE021420 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KLEIN, OPHIR D · 2011 to 2015
$2.0M
NIDCR Dentist Scientist K99;Function and Regulation of Perp in AmelogenesisK99DE022059 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JHEON, ANDREW H. · 2011 to 2012
$255k
NIDCR NIH HHS K99 DE022059NIDCR NIH HHS K99-DE022059NIDCR NIH HHS R01 DE021420NIDCR NIH HHS R01-DE021420NIH HHS DP2 OD007191NIH HHS DP2-OD007191
6 · The paper itself

Abstract

Teeth are unique to vertebrates and have played a central role in their evolution. The molecular pathways and morphogenetic processes involved in tooth development have been the focus of intense investigation over the past few decades, and the tooth is an important model system for many areas of research. Developmental biologists have exploited the clear distinction between the epithelium and the underlying mesenchyme during tooth development to elucidate reciprocal epithelial/mesenchymal interactions during organogenesis. The preservation of teeth in the fossil record makes these organs invaluable for the work of paleontologists, anthropologists, and evolutionary biologists. In addition, with the recent identification and characterization of dental stem cells, teeth have become of interest to the field of regenerative medicine. Here, we review the major research areas and studies in the development and evolution of teeth, including morphogenesis, genetics and signaling, evolution of tooth development, and dental stem cells.

Indexed as

Metabolic Networks and PathwaysAnimalsBiological EvolutionEpitheliumGene Expression Regulation, DevelopmentalMasticationMesodermMorphogenesisOdontogenesisStem CellsTooth

Identifiers

PMID24009032
PMCPMC3632217

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.