ArticleJournal of applied physiology (Bethesda, Md. : 1985)2013
Cerebrovascular autoregulation after rewarming from hypothermia in a neonatal swine model of asphyxic brain injury.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 44 citations in OpenAlex.
- How to optimize brain perfusion and prevent cerebral complications during extracorporeal life support.Intensive care medicine · 2026Review
- Short and long-term outcomes in neonatal hypoxic-ischemic encephalopathy treated with hypothermia and vasoactive medications.Paediatrics & child health · 2025Article
- Towards quantitative assessment of cerebrovascular autoregulation in human neonates using ultrafast ultrasound imaging.Scientific reports · 2025Article
- Monitoring of cerebral blood flow autoregulation: physiologic basis, measurement, and clinical implications.British journal of anaesthesia · 2024Review
- Quantification of Cerebral Vascular Autoregulation Immediately Following Resuscitation from Cardiac Arrest.Annals of biomedical engineering · 2023Article
- Contrast-enhanced subharmonic aided pressure estimation for assessment of intracranial pressure in vivo.Pediatric radiology · 2023Article
- The utility of therapeutic hypothermia on cerebral autoregulation.Journal of intensive medicine · 2023Review
- Development of a neonatal Göttingen Minipig model for dose precision in perinatal asphyxia: technical opportunities, challenges, and potential further steps.Frontiers in pediatrics · 2023Review
- The Utility of Cerebral Autoregulation Indices in Detecting Severe Brain Injury Varies by Cooling Treatment Phase in Neonates with Hypoxic-Ischemic Encephalopathy.Developmental neuroscience · 2022Observational
- Regulation of the Cerebral Circulation During Development.Comprehensive Physiology · 2021Article
- Article
- Fractional anisotropy from diffusion tensor imaging correlates with acute astrocyte and myelin swelling in neonatal swine models of excitotoxic and hypoxic-ischemic brain injury.The Journal of comparative neurology · 2021Article
- Nutraceuticals in the Prevention of Neonatal Hypoxia-Ischemia: A Comprehensive Review of their Neuroprotective Properties, Mechanisms of Action and Future Directions.International journal of molecular sciences · 2021Review
- Combining Hypothermia and Oleuropein Subacutely Protects Subcortical White Matter in a Swine Model of Neonatal Hypoxic-Ischemic Encephalopathy.Journal of neuropathology and experimental neurology · 2021Article
- Wavelet Autoregulation Monitoring Identifies Blood Pressures Associated With Brain Injury in Neonatal Hypoxic-Ischemic Encephalopathy.Frontiers in neurology · 2021Article
- Continuous Time-Domain Cerebrovascular Reactivity Metrics and Discriminate Capacity for the Upper and Lower Limits of Autoregulation: A Scoping Review of the Animal Literature.Neurotrauma reports · 2021Article
- Mean Diffusivity in Striatum Correlates With Acute Neuronal Death but Not Lesser Neuronal Injury in a Pilot Study of Neonatal Piglets With Encephalopathy.Journal of magnetic resonance imaging : JMRI · 2020Article
- Comparison of wavelet and correlation indices of cerebral autoregulation in a pediatric swine model of cardiac arrest.Scientific reports · 2020Article
- Spatial T-maze identifies cognitive deficits in piglets 1 month after hypoxia-ischemia in a model of hippocampal pyramidal neuron loss and interneuron attrition.Behavioural brain research · 2019Article
- Hypoxia-Ischemia and Hypothermia Independently and Interactively Affect Neuronal Pathology in Neonatal Piglets with Short-Term Recovery.Developmental neuroscience · 2019Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
After hypoxic brain injury, maintaining blood pressure within the limits of cerebral blood flow autoregulation is critical to preventing secondary brain injury. Little is known about the effects of prolonged hypothermia or rewarming on autoregulation after cardiac arrest. We hypothesized that rewarming would shift the lower limit of autoregulation (LLA), that this shift would be detected by indices derived from near-infrared spectroscopy (NIRS), and that rewarming would impair autoregulation during hypertension. Anesthetized neonatal swine underwent sham surgery or hypoxic-asphyxic cardiac arrest, followed by 2 h of normothermia and 20 h of hypothermia, with or without rewarming. Piglets were further divided into cohorts for cortical laser-Doppler flow (LDF) measurements during induced hypotension or hypertension. We also tested whether indices derived from NIRS could identify the LDF-derived LLA. The LLA did not differ significantly among groups with sham surgery and hypothermia (29 ± 8 mmHg), sham surgery and rewarming (34 ± 7 mmHg), arrest and hypothermia (29 ± 10 mmHg), and arrest and rewarming (38 ± 11 mmHg). The LLA was not affected by arrest (P = 0.60), temperature (P = 0.08), or interaction between arrest and temperature (P = 0.73). The NIRS-derived indices detected the LLA accurately, with the area under the receiver-operator characteristic curves of 0.81-0.96 among groups. In groups subjected to arrest and hypothermia, with or without rewarming, the slope of LDF relative to cerebral perfusion pressure during hypertension was not significantly different from zero (P > 0.10). In conclusion, rewarming did not shift the LLA during hypotension or affect autoregulation during hypertension after asphyxic cardiac arrest. The NIRS-derived autoregulation indices identified the LLA accurately.
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