ArticleJournal of biomedical optics2013
Ultrastructural alterations in field carcinogenesis measured by enhanced backscattering spectroscopy.
Article in Journal of biomedical optics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Feasibility of non-imaging, random-sampling second harmonic generation measurements to distinguish colon cancer.Biophotonics discovery · 2024Article
- Cancer characterization using light backscattering spectroscopy and quantitative ultrasound: an ex vivo study on sarcoma subtypes.Scientific reports · 2023Article
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- Assessment of internal refractive index profile of stochastically inhomogeneous nuclear models via analysis of two-dimensional optical scattering patterns.Journal of biomedical optics · 2021Article
- Platform for quantitative multiscale imaging of tissue composition.Biomedical optics express · 2020Article
- Preservation of cellular nano-architecture by the process of chemical fixation for nanopathology.PloS one · 2019Article
- Optical detection of field cancerization in the buccal mucosa of patients with esophageal cancer.Clinical and translational gastroenterology · 2018Article
- Microscope objective based 4Biomedical optics express · 2017Article
- Using electron microscopy to calculate optical properties of biological samples.Biomedical optics express · 2016Article
- Enhanced Survival with Implantable Scaffolds That Capture Metastatic Breast Cancer Cells In Vivo.Cancer research · 2016Article
- Fractal propagation method enables realistic optical microscopy simulations in biological tissues.Optica · 2016Article
- Fractal Characterization of Chromatin Decompaction in Live Cells.Biophysical journal · 2015Article
- Rectal Optical Markers for In Vivo Risk Stratification of Premalignant Colorectal Lesions.Clinical cancer research : an official journal of the American Association for Cancer Research · 2015Article
- In vivo capture and label-free detection of early metastatic cells.Nature communications · 2015Article
- In vivo risk analysis of pancreatic cancer through optical characterization of duodenal mucosa.Pancreas · 2015Article
- Prediction of prostate cancer recurrence using quantitative phase imaging.Scientific reports · 2015Article
- Subdiffusion reflectance spectroscopy to measure tissue ultrastructure and microvasculature: model and inverse algorithm.Journal of biomedical optics · 2015Article
- Spatially resolved optical and ultrastructural properties of colorectal and pancreatic field carcinogenesis observed by inverse spectroscopic optical coherence tomography.Journal of biomedical optics · 2014Article
- Buccal spectral markers for lung cancer risk stratification.PloS one · 2014Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Optical characterization of biological tissue in field carcinogenesis offers a method with which to study the mechanisms behind early cancer development and the potential to perform clinical diagnosis. Previously, low-coherence enhanced backscattering spectroscopy (LEBS) has demonstrated the ability to discriminate between normal and diseased organs based on measurements of histologically normal-appearing tissue in the field of colorectal (CRC) and pancreatic (PC) cancers. Here, we implement the more comprehensive enhanced backscattering (EBS) spectroscopy to better understand the structural and optical changes which lead to the previous findings. EBS provides high-resolution measurement of the spatial reflectance profile P(rs) between 30 microns and 2.7 mm, where information about nanoscale mass density fluctuations in the mucosa can be quantified. A demonstration of the length-scales at which P(rs) is optimally altered in CRC and PC field carcinogenesis is given and subsequently these changes are related to the tissue's structural composition. Three main conclusions are made. First, the most significant changes in P(rs) occur at short length-scales corresponding to the superficial mucosal layer. Second, these changes are predominantly attributable to a reduction in the presence of subdiffractional structures. Third, similar trends are seen for both cancer types, suggesting a common progression of structural alterations in each.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.