ArticleThe Journal of antimicrobial chemotherapy2014
Fourth Belgian multicentre survey of antibiotic susceptibility of anaerobic bacteria.
Article in The Journal of antimicrobial chemotherapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 164 citations in OpenAlex.
- Metronidazole Susceptibility Patterns in EuropeanMedical sciences (Basel, Switzerland) · 2026Pooled it
- The emergence and biological characteristics of linezolid-resistantEmerging microbes & infections · 2026Article
- Natural and synthetic antimicrobial peptides against anaerobic bacteria: A review of activities and mechanisms of action.Probiotics and antimicrobial proteins · 2026Review
- Detection Blind Spots in Microbial Culture, tNGS, and mNGS: Anaerobic Bacterial Infections in the Lung-A Retrospective Analysis of Two Cases.Infection and drug resistance · 2026Article
- ThePeerJ · 2025Review
- The emergence of metronidazole-resistantMicrobiology spectrum · 2024Article
- Detection of the antibiotic resistance genes content of intestinal Bacteroides, Parabacteroides and Phocaeicola isolates from healthy and carbapenem-treated patients from European countries.BMC microbiology · 2024Article
- Distribution, Trends, and Antimicrobial Susceptibility ofOpen forum infectious diseases · 2023Article
- Recent Trends in Antimicrobial Resistance among Anaerobic Clinical Isolates.Microorganisms · 2023Review
- Anaerobic Gram-Negative Bacteria: Role as a Reservoir of Antibiotic Resistance.Antibiotics (Basel, Switzerland) · 2023Article
- Bacteremia caused by Clostridium sporogenes in an oncological patient.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2023Article
- Antimicrobial Susceptibility Profile of Rare Anaerobic Bacteria.Antibiotics (Basel, Switzerland) · 2022Article
- Article
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- Antimicrobial Susceptibility Patterns and Wild-Type MIC Distributions of Anaerobic Bacteria at a German University Hospital: A Five-Year Retrospective Study (2015-2019).Antibiotics (Basel, Switzerland) · 2020Article
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- Breast Abscesses Caused by Anaerobic Microorganisms: Clinical and Microbiological Characteristics.Antibiotics (Basel, Switzerland) · 2020Article
- Water Sources in a Zoological Park Harbor Genetically Diverse Strains of Clostridium Perfringens Type A with Decreased Susceptibility to Metronidazole.Microbial ecology · 2016Article
- Epidemiology and antimicrobial susceptibilities of wound isolates of obligate anaerobes from combat casualties.Diagnostic microbiology and infectious disease · 2016Article
- Clinical and microbiological characteristics of Eggerthella lenta bacteremia.Journal of clinical microbiology · 2015Article
Corrections and comments
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Authors and funding
13 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo collect recent data on the susceptibility of anaerobes to antimicrobial agents with known activity against anaerobes, and to compare them with results from previous Belgian multicentre studies.
methodsFour hundred and three strict anaerobic clinical isolates were prospectively collected from February 2011 to April 2012 in eight Belgian university hospitals. MICs were determined by one central laboratory for 11 antimicrobial agents using Etest methodology.
resultsAccording to EUCAST breakpoints, >90% of isolates were susceptible to amoxicillin/clavulanate (94%), piperacillin/tazobactam (91%), meropenem (96%), metronidazole (92%) and chloramphenicol (98%), but only 70% and 40% to clindamycin and penicillin, respectively. At CLSI recommended breakpoints, only 71% were susceptible to moxifloxacin and 79% to cefoxitin. MIC50/MIC90 values for linezolid and for tigecycline were 1/4 and 0.5/4 mg/L, respectively. When compared with survey data from 2004, no major differences in susceptibility profiles were noticed. However, the susceptibility of Prevotella spp. and other Gram-negative bacilli to clindamycin decreased from 91% in 1993-94 and 82% in 2004 to 69% in this survey. Furthermore, the susceptibility of clostridia to moxifloxacin decreased from 88% in 2004 to 66% in 2011-12 and that of fusobacteria from 90% to 71%.
conclusionsCompared with previous surveys, little evolution was seen in susceptibility, except a decline in activity of clindamycin against Prevotella spp. and other Gram-negative bacteria, and of moxifloxacin against clostridia. Since resistance was detected to all antibiotics, susceptibility testing of anaerobic isolates is indicated in severe infections to confirm appropriateness of antimicrobial therapy.
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