ArticleScientific reports2013
Distinct cell shapes determine accurate chemotaxis.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 82 citations in OpenAlex.
- Reply to van Haastert: Local competition between Ras/actin-driven protrusions.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Simulation-based inference of cell migration dynamics in complex spatial environments.NPJ systems biology and applications · 2026Article
- Persistent pseudopod splitting is an effective chemotaxis strategy in shallow gradients.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Cellular morphodynamics as quantifiers for functional states of resident tissue macrophages in vivo.PLoS computational biology · 2025Article
- Cell shape and orientation control galvanotactic accuracy.Soft matter · 2024Article
- Cell deformability drives fluid-to-fluid phase transition in active cell monolayers.Science advances · 2024Article
- Three-component contour dynamics model to simulate and analyze amoeboid cell motility in two dimensions.PloS one · 2024Article
- Crawling, waving, inch worming, dilating, and pivoting mechanics of migrating cells: Lessons from Ken Jacobson.Biophysical journal · 2023Review
- Deformability and collision-induced reorientation enhance cell topotaxis in dense microenvironments.Biophysical journal · 2023Article
- Morphomigrational description as a new approach connecting cell's migration with its morphology.Scientific reports · 2023Article
- A deep learning approach for morphological feature extraction based on variational auto-encoder: an application to mandible shape.NPJ systems biology and applications · 2023Article
- Random walk and cell morphology dynamics inFrontiers in cell and developmental biology · 2023Article
- Traject3d allows label-free identification of distinct co-occurring phenotypes within 3D culture by live imaging.Nature communications · 2022Article
- T cell morphodynamics reveal periodic shape oscillations in three-dimensional migration.Journal of the Royal Society, Interface · 2022Article
- Physics-informed deep learning characterizes morphodynamics of Asian soybean rust disease.Nature communications · 2021Article
- Comparative mapping of crawling-cell morphodynamics in deep learning-based feature space.PLoS computational biology · 2021Article
- Local actin dynamics couple speed and persistence in a cellular Potts model of cell migration.Biophysical journal · 2021Article
- Article
- Equilibrium structure and deformation response of 2D kinetoplast sheets.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Persistent and polarized global actin flow is essential for directionality during cell migration.Nature cell biology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
The behaviour of an organism often reflects a strategy for coping with its environment. Such behaviour in higher organisms can often be reduced to a few stereotyped modes of movement due to physiological limitations, but finding such modes in amoeboid cells is more difficult as they lack these constraints. Here, we examine cell shape and movement in starved Dictyostelium amoebae during migration toward a chemoattractant in a microfluidic chamber. We show that the incredible variety in amoeboid shape across a population can be reduced to a few modes of variation. Interestingly, cells use distinct modes depending on the applied chemical gradient, with specific cell shapes associated with shallow, difficult-to-sense gradients. Modelling and drug treatment reveals that these behaviours are intrinsically linked with accurate sensing at the physical limit. Since similar behaviours are observed in a diverse range of cell types, we propose that cell shape and behaviour are conserved traits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.