ArticleInvestigative ophthalmology & visual science2013
Computational model for oxygen transport and consumption in human vitreous.
Article in Investigative ophthalmology & visual science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Macula-vitreous interface vitrectomy for pediatric epiretinal membrane: surgical principles, clinical outcomes and safety profile.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Sub-Internal Limiting Membrane Hemorrhage: Molecular Microenvironment and Review of Treatment Modalities.International journal of molecular sciences · 2026Review
- Clinical Management of Vision Degrading Myodesopsia from Vitreous Floaters: Observation vs. Limited Refractive Vitrectomy.Ophthalmology. Retina · 2025Article
- Increased Risk of Omidenepag Isopropyl-Induced Cystoid Macular Edema Following Pars Plana Vitrectomy: A Case Report.Korean journal of ophthalmology : KJO · 2025Article
- Vitreous Substitutes as Drug Release Systems.Translational vision science & technology · 2022Review
- Predicting speed of progression of lens opacification after pars plana vitrectomy with silicone oil.PloS one · 2022Article
- Vitreous function and intervention of it with vitrectomy and other modalities.International journal of ophthalmology · 2022Article
- The plasminogen protein is associated with high myopia as revealed by the iTRAQ-based proteomic analysis of the aqueous humor.Scientific reports · 2021Article
- Article
- Pars Plana Vitrectomy and the Risk of Ocular Hypertension and Glaucoma: Where Are We?Journal of clinical medicine · 2020Review
- Retinal oxygen: from animals to humans.Progress in retinal and eye research · 2017Review
- Organization of lipids in fiber-cell plasma membranes of the eye lens.Experimental eye research · 2017Review
- Lens glutathione homeostasis: Discrepancies and gaps in knowledge standing in the way of novel therapeutic approaches.Experimental eye research · 2017Review
- Spatial Variations in Vitreous Oxygen Consumption.PloS one · 2016Article
- Quantitative imaging of enzymatic vitreolysis-induced fiber remodeling.Investigative ophthalmology & visual science · 2014Article
- Preservation of the structure of enzymatically-degraded bovine vitreous using synthetic proteoglycan mimics.Investigative ophthalmology & visual science · 2014Article
- Enzymatic degradation identifies components responsible for the structural properties of the vitreous body.Investigative ophthalmology & visual science · 2014Article
- Vitreous substitutes: the present and the future.BioMed research international · 2014Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
purposePrevious studies that measured liquefaction and oxygen content in human vitreous suggested that exposure of the lens to excess oxygen causes nuclear cataracts. Here, we developed a computational model that reproduced available experimental oxygen distributions for intact and degraded human vitreous in physiologic and environmentally perturbed conditions. After validation, the model was used to estimate how age-related changes in vitreous physiology and structure alter oxygen levels at the lens.
methodsA finite-element model for oxygen transport and consumption in the human vitreous was created. Major inputs included ascorbate-mediated oxygen consumption in the vitreous, consumption at the posterior lens surface, and inflow from the retinal vasculature. Concentration-dependent relations were determined from experimental human data or estimated from animal studies, with the impact of all assumptions explored via parameter studies.
resultsThe model reproduced experimental data in humans, including oxygen partial pressure (Po2) gradients (≈15 mm Hg) across the anterior-posterior extent of the vitreous body, higher oxygen levels at the pars plana relative to the vitreous core, increases in Po2 near the lens after cataract surgery, and equilibration in the vitreous chamber following vitrectomy. Loss of the antioxidative capacity of ascorbate increases oxygen levels 3-fold at the lens surface. Homogeneous vitreous degeneration (liquefaction), but not partial posterior vitreous detachment, greatly increases oxygen exposure to the lens.
conclusionsAscorbate content and the structure of the vitreous gel are critical determinants of lens oxygen exposure. Minimally invasive surgery and restoration of vitreous structure warrant further attention as strategies for preventing nuclear cataracts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.