ArticleEndocrine connections2013
The age factor in survival of a population cohort of well-differentiated thyroid cancer.
Article in Endocrine connections, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of prophylactic central neck dissection following total thyroidectomy on surgical site wound infection, hematoma, and haemorrhage in subjects with clinically node-negative papillary thyroid carcinoma: A meta-analysis.International wound journal · 2023Pooled it
- Prognostic factors evaluated in differentiated thyroid carcinomas.Endocrine connections · 2026Review
- Survival trends and conditional survival in patients with pulmonary metastases from differentiated thyroid carcinoma.Endocrine · 2025Article
- Multiple Lung Metastases of Papillary Thyroid Carcinoma Detected by Detailed Pathological Examination: A Case Series.Cureus · 2025Article
- Long-Term Survival Rate for Moroccan Patients with Differentiated Thyroid Cancer.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- A Nomogram for Predicting Lung Metastasis in Papillary Thyroid Cancer Patients Aged Less Than 55 Years.Frontiers in endocrinology · 2025Article
- Assessing radioiodine therapy long-term outcomes in differentiated thyroid cancer using nomograms.Scientific reports · 2024Article
- Prognostic factors of papillary and follicular carcinomas based on pre-, intra-, and post-operative findings.European thyroid journal · 2024Review
- Analysis of the ideal cutoff age as a predictor of differentiated thyroid cancer using the Surveillance, Epidemiology, and End Results database.Translational cancer research · 2024Article
- Disparities in Thyroid Cancer Diagnosis Based on Residence and Distance From Medical Facility.Journal of the Endocrine Society · 2024Article
- Knowledge, Awareness and Perception towards Thyroid Cancer in General Population: A Systematic Review.Iranian journal of public health · 2023Review
- A practical dynamic nomogram model for predicting bone metastasis in patients with thyroid cancer.Frontiers in endocrinology · 2023Article
- An ultrasound model for predicting recurrence of papillary thyroid carcinoma after complete endoscopic resection.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2022Article
- Prediction of lung metastases in thyroid cancer using machine learning based on SEER database.Cancer medicine · 2022Article
- PSG7 indicates that age at diagnosis is associated with papillary thyroid carcinoma: A study based on the cancer genome atlas data.Frontiers in genetics · 2022Article
- Machine learning for the prediction of bone metastasis in patients with newly diagnosed thyroid cancer.Cancer medicine · 2021Article
- Impact of the 8International journal of endocrinology · 2021Article
- Age Influences the Prognosis of Anaplastic Thyroid Cancer Patients.Frontiers in endocrinology · 2021Article
- The new AJCC/TNM Staging System (VIII ed.) in papillary thyroid cancer: clinical and molecular impact on overall and recurrence free survival.Annals of translational medicine · 2020Article
- Older Age Significantly Affects Mortality of Patients with Papillary Thyroid Carcinoma Only When They Have High-Risk Features.World journal of surgery · 2020Article
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Well-differentiated thyroid carcinoma (WDTC) represents a group of thyroid cancers with excellent prognosis. Age, a well-recognized risk factor for WDTC, has been consistently included in various prognostic scoring systems. An age threshold of 45 years is currently used by the American Joint Cancer Committee-TNM staging system for the risk stratification of patients. This study analyzes the relationship between the patients' age at diagnosis and thyroid cancer-specific survival in a population-based thyroid cancer cohort of 2115 consecutive patients with WDTC, diagnosed during 1970-2010, and evaluates the appropriateness of the currently used age threshold. Oncological outcomes of patients in terms of disease-specific survival (DSS) and disease-free survival (DFS) were calculated by the Kaplan-Meier method, while multivariable analysis was done by the Cox proportional hazard model and proportional hazards regression for sub-distribution of competing risks to assess the independent influence of various prognostic factors. The mean age of the patients was 47.3 years, 76.6% were female and 83.3% had papillary carcinoma. The median follow-up of the cohort was 122.4 months. The DSS and DFS were 95.4 and 92.8% at 10 years and 90.1 and 87.6% at 20 years, respectively. Multivariable analyses confirmed patient's age to be an independent risk factor adversely affecting the DSS but not the DFS. Distant metastasis, incomplete surgical resection, T3/T4 stages, Hürthle cell histology, and male gender were other independent prognostic determinants. The DSS was not independently influenced by age until the age of 55 years. An age threshold of 55 years is better than that of 45 years for risk stratification.
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