Trial reportThe neuroradiology journal2013
Cerebrovascular reactivity across the menstrual cycle in young healthy women.
Trial report in The neuroradiology journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 44 citations in OpenAlex.
- Effects of continuous hypoxia on flow-mediated dilation in the cerebral and systemic circulation: on the regulatory significance of shear rate phenotype.The journal of physiological sciences : JPS · 2022Trial
- Endocrine modulation of cortical and retinal baseline perfusion across the menstrual cycle.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Article
- Short-Term Gingival Microcirculatory Responses to Non-Invasive Physical Stimulation: Implications for Accelerated Orthodontic Research.Dentistry journal · 2026Article
- Decreases in Hormone Levels Modulate Neurovascular Coupling but Not Reduced Insular Functional Connectivity in Menstrual-Related Migraine.Human brain mapping · 2025Article
- Doppler Ultrasound Assessment of Blood Flow Indices in Childbearing Age Women Across the Menstrual Cycle.Medicina (Kaunas, Lithuania) · 2025Article
- Evaluating Cerebral Blood Flow among Patients Experiencing Premenstrual Syndrome with Headache using Duplex Ultrasonography.Current medical imaging · 2025Article
- Menstrual cycle does not impact the hypoxic ventilatory response and acute mountain sickness prediction.Scientific reports · 2024Article
- The effect of posture on the age dependence of neurovascular coupling.Physiological reports · 2024Article
- Cerebral autoregulation across the menstrual cycle in eumenorrheic women.Physiological reports · 2022Article
- Effect of breath-hold on the responses of arterial blood pressure and cerebral blood velocity to isometric exercise.European journal of applied physiology · 2022Article
- Menstrual phase influences cerebrovascular responsiveness in females but may not affect sex differences.Frontiers in physiology · 2022Article
- Changes in white matter microstructure and MRI-derived cerebral blood flow after 1-week of exercise training.Scientific reports · 2021Article
- Integrative cardiovascular control in women: Regulation of blood pressure, body temperature, and cerebrovascular responsiveness.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Review
- Sex moderations in the relationship between aortic stiffness, cognition, and cerebrovascular reactivity in healthy older adults.PloS one · 2021Article
- Dynamic community detection reveals transient reorganization of functional brain networks across a female menstrual cycle.Network neuroscience (Cambridge, Mass.) · 2021Article
- Female Sex Hormone Effects on the Vasculature: Considering the Validity of Restricting Study Inclusion to Low-Hormone Phases.Frontiers in physiology · 2020Article
- Perivascular neurotransmitters: Regulation of cerebral blood flow and role in primary headaches.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Review
- Dynamic cerebral autoregulation after confinement in an isolated environment for 14 days.Environmental health and preventive medicine · 2018Article
- Effect of the menstrual cycle on circulation during combined spinal-epidural anaesthesia.BMC anesthesiology · 2018Article
- Cerebral blood flow changes during tilt table testing in healthy volunteers, as assessed by Doppler imaging of the carotid and vertebral arteries.Clinical neurophysiology practice · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study evaluated the relationship of cerebrovascular reactivity in young healthy women with changes in concentrations of circulating ovarian hormones throughout the menstrual cycle. Nineteen healthy nulliparous, right-handed, regularly menstruating women (age 23-25 years) underwent color-coded duplex sonography of the common (CCA), internal (ICA) and external (ECA) carotid arteries on both sides. Mean blood flow velocity values measured before and ten minutes after intravenous administration of 1000 mg acetazolamide (ACE) were assessed in relation to the serum concentration of estrogen and progesterone on days 5, 13 and 26 of the cycle. After ACE administration flow velocity in the right CCA and ICA increased by 23% and 35% on day 5, 12% and 31% on day 13 and 30% and 47% on day 26 respectively, and the changes were significantly larger on the right side (F=6.793 and F=4.098 respectively; both p<0.05). Changes in blood flow velocity in the right CCA and ICA after ACE injection were significantly associated with ovarian hormone concentrations (F=3.828, P=0.028 and F=3.671, P=0.032 respectively). We conclude that cerebrovascular reactivity changes across the menstrual cycle are associated with ovarian steroid hormone changes, and are asymmetric. The results imply that vasculature of the right hemisphere may undergo cyclic vasodilation across the menstrual cycle and this effect should be considered in studies of cerebrovascular reactivity in women with migraine and mood disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.