Trial reportThe neuroradiology journal2013
Semiautomatic regional segmentation to measure orbital fat volumes in thyroid-associated ophthalmopathy. A validation study.
Trial report in The neuroradiology journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review on volumetric analysis in orbital MRI.Neuroradiology · 2025Pooled it
- The INI-32 dataset: An annotated computed tomography atlas of the orbit.Data in brief · 2026Article
- Deep Learning Model for Automated Segmentation of Orbital Structures in MRI Images.Clinical neuroradiology · 2025Article
- Prediction of exophthalmos by body mass index for craniofacial reconstruction: consequences for cold cases.Forensic science, medicine, and pathology · 2024Article
- Computer aided volumetric assessment of orbital structures in patients with Graves' orbitopathy: correlation with serum thyroid antiperoxidase antibodies and disease activity.International ophthalmology · 2023Review
- Deep-Learning-Based Segmentation of Extraocular Muscles from Magnetic Resonance Images.Bioengineering (Basel, Switzerland) · 2023Article
- Computed tomography and magnetic resonance imaging approaches to Graves' ophthalmopathy: a narrative review.Frontiers in endocrinology · 2023Review
- Prospective Evaluation of Intraorbital Soft Tissue Atrophy after Posttraumatic Bone Reconstruction: A Risk Factor for Enophthalmos.Journal of personalized medicine · 2022Article
- The role of ultrasonography in differential diagnosis of orbital lesions.Journal of ultrasound · 2021Article
- Orbital myeloid sarcoma (chloroma): Report of 2 cases and literature review.American journal of ophthalmology case reports · 2020Article
- An accurate interactive segmentation and volume calculation of orbital soft tissue for orbital reconstruction after enucleation.BMC ophthalmology · 2019Article
- Thyroid-associated Orbitopathy: Quantitative Evaluation of the Orbital Fat Volume and Edema Using IDEAL-FSE.European journal of radiology open · 2019Article
- [A novel method for quantitative measurement of orbital fat volume based on magnetic resonance images].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2017Article
- Radiotherapy for the treatment of thyroid eye disease-a prospective comparison: Is orbital radiotherapy a suitable alternative to steroids?Irish journal of medical science · 2017Article
- Pingmu Decoction Induces Orbital Preadipocytes Apoptosis In Vitro.Evidence-based complementary and alternative medicine : eCAM · 2017Article
- Orbital Fat Volumetry and Water Fraction Measurements Using T2-Weighted FSE-IDEAL Imaging in Patients with Thyroid-Associated Orbitopathy.AJNR. American journal of neuroradiology · 2016Article
- Model-based segmentation in orbital volume measurement with cone beam computed tomography and evaluation against current concepts.International journal of computer assisted radiology and surgery · 2016Article
- Graves' Ophthalmopathy: VISA versus EUGOGO Classification, Assessment, and Management.Journal of ophthalmology · 2015Review
- Orbital metastases in Italy.International journal of ophthalmology · 2015Article
- Methotrexate for the treatment of thyroid eye disease.Journal of ophthalmology · 2014Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study was designed to validate a novel semi-automated segmentation method to measure regional intra-orbital fat tissue volume in Graves' ophthalmopathy. Twenty-four orbits from 12 patients with Graves' ophthalmopathy, 24 orbits from 12 controls, ten orbits from five MRI study simulations and two orbits from a digital model were used. Following manual region of interest definition of the orbital volumes performed by two operators with different levels of expertise, an automated procedure calculated intra-orbital fat tissue volumes (global and regional, with automated definition of four quadrants). In patients with Graves' disease, clinical activity score and degree of exophthalmos were measured and correlated with intra-orbital fat volumes. Operator performance was evaluated and statistical analysis of the measurements was performed. Accurate intra-orbital fat volume measurements were obtained with coefficients of variation below 5%. The mean operator difference in total fat volume measurements was 0.56%. Patients had significantly higher intra-orbital fat volumes than controls (p<0.001 using Student's t test). Fat volumes and clinical score were significantly correlated (p<0.001). The semi-automated method described here can provide accurate, reproducible intra-orbital fat measurements with low inter-operator variation and good correlation with clinical data.
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